乳酸锌和氟化亚锡对铜绿假单胞菌、鲍曼不动杆菌和变异链球菌生物被膜的抑制作用

发布时间：2018-07-07 22:55

  本文选题：铜绿假单胞菌 + 乳酸锌　； 参考：《生物工程学报》2017年09期

【摘要】：乳酸锌(Zn lactate·3H_2O)和氟化亚锡(SnF_2)常作为牙膏中的活性物质添加剂用来预防龋齿及口腔生物被膜的形成。文中评估了Zn lactate·3H_2O和SnF_2对铜绿假单胞菌、鲍曼不动杆菌和变异链球菌生物被膜的作用。对铜绿假单胞菌PAO1生物被膜的抑制实验证实乳酸锌和氟化亚锡都具有抑制其生物被膜的功能,联用效果尤佳。乳酸锌通过干扰胞外多糖基质网的形成起作用,而氟化亚锡则可以明显降低生物被膜的生物量。更为重要的是,工作浓度的两种化合物联用几乎可以完全抑制3种实验菌株生物被膜的形成。
[Abstract]:Zinc lactate (Zn lactate. 3H_2O) and stannous fluoride (SnF_2) are often used as active additives in toothpaste to prevent dental caries and oral biofilm formation. In this paper, the effects of Zn lactate. 3H_2O and SnF_2 on Pseudomonas aeruginosa, Acinetobacter Bauman and Streptococcus mutans biofilm, PAO1 biofilm of Pseudomonas aeruginosa, were evaluated. The inhibition experiments confirm that zinc lactate and stannous fluoride have the function of inhibiting their biofilm. The combination effect is excellent. Zinc lactate can play a role by interfering with the formation of extracellular polysaccharide matrix network, while stannous fluoride can obviously reduce the biomass of biofilm. More importantly, the two compounds of the working concentration can be used almost completely. Inhibition of the formation of the biofilm of the 3 experimental strains.
【作者单位】： 中国科学院微生物研究所;中国科学院大学;
【基金】：国家重点基础研究发展计划(973计划)(No.2014CB846002) 国家自然科学基金(No.31570126) 北京宝洁技术有限公司资助~~
【分类号】：R78;TQ658.41
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本文编号：2106549