辅助性T细胞亚群与牙周炎的免疫损伤机制

发布时间：2018-07-08 09:04

本文选题：牙周炎 + 辅助性T细胞亚群　；参考：《国际口腔医学杂志》2017年01期

【摘要】：牙周炎症组织破坏与机体针对致病菌及其毒性产物的免疫反应方式有关,辅助性T细胞(T_h)亚群通过分泌不同的细胞因子发挥免疫调节功能。较早发现的T_h1和T_h2分别介导细胞免疫和体液免疫,二者相互抑制保持平衡,牙周炎症的间断性和进展性与T_h1/T_h2主导的免疫反应的平衡破坏有关。在牙周炎早期和静止期,表现为T_h1反应类型;在牙周炎晚期或活动期,则表现为T_h2反应类型。T_h17具有重要的促进牙周慢性炎症及免疫损伤形成的作用,而调节性T细胞(T_(reg))则具有炎症抑制作用,而且T_h17/T_(reg)在功能和分化上也具有与T_h1/T_h2类似的相互调节相互抑制的平衡关系。T_h17/T_(reg)和T)h1/T)h2在局部形成复杂的细胞因子网络,是目前进一步研究牙周炎的免疫病理学机制的热点。
[Abstract]:The tissue destruction of periodontitis is related to the immune response to pathogenic bacteria and its toxic products. The T lymphocyte subsets (Th) play an immunomodulatory role by secreting different cytokines. Earlier discovery of Th1 and THA2 mediated cellular and humoral immunity respectively. The intersuppressive balance between them was maintained. The discontinuity and progression of periodontitis were related to the disruption of Th1 / TH2 dominated immune response. In the early and stationary period of periodontitis, the type of Th1 response was shown as Th1, and in the late or active stage of periodontitis, the type of Th2 reaction. Th17 played an important role in promoting the formation of chronic periodontal inflammation and immune injury. On the other hand, regulatory T cells (T _ (reg) have inflammatory inhibitory effect, and T _ H _ 17 / T _ (reg) has a similar balance of interregulation and inhibition with Th _ H _ 1 / Th _ 2 in function and differentiation. Th _ H _ 17 / T _ (reg) and T) h _ 1 / T) h2 form a complex network of cytokines locally. It is a hot point to further study the immunopathological mechanism of periodontitis.
【作者单位】：河北医科大学口腔医院口腔内科;衡水哈励逊国际和平医院耳鼻喉科;
【分类号】：R781.42

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