牙周病与早产低体重儿的关系及其机制的研究进展

发布时间：2018-07-17 04:29

【摘要】：早产是指新生儿出生时胎龄未满37周,低体重儿是指新生儿出生时体重未满2 500 g,早产常伴发低体重儿。早产被认为是新生儿死亡的主要原因。牙周病是一种口腔常见的慢性感染性疾病,与全身多种系统性疾病具有相关性。流行病学资料表明牙周病与早产低体重儿具有一定相关性,牙周病是早产低体重儿等不良妊娠结局的危险因素之一,可能的机制包括牙周致病菌菌体的直接作用,引起机体炎症反应和过激免疫反应等,然而具体的机制尚未明确。本文就牙周病与早产低体重儿的相关性,开展牙周治疗对早产低体重儿发生率的影响,以及牙周病引发早产低体重儿的相关机制作一综述。
[Abstract]:Premature birth refers to the birth age of newborns is less than 37 weeks, low birth weight refers to the birth weight of the newborn is less than 2 500 g, preterm birth is often accompanied by low birth weight infants. Premature birth is considered the leading cause of neonatal death. Periodontal disease is a common chronic infectious disease in oral cavity, which is related to many systemic diseases. Epidemiological data show that periodontal disease is associated with premature low birth weight infants. Periodontal disease is one of the risk factors of poor pregnancy outcome such as premature low birth weight infants. The possible mechanism includes the direct action of periodontal pathogenic bacteria. It causes inflammatory reaction and excessive immune response, but the specific mechanism is not clear. This article reviews the relationship between periodontal disease and premature low birth weight infants, the effect of periodontal therapy on the incidence of preterm low birth weight infants, and the mechanism of periodontal disease causing low birth weight premature infants.
【作者单位】：口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙周病科;
【基金】：国家自然科学基金青年基金(81600875) 成都市科技局科技惠民技术研发项目(2015-HM01-00088-SF) 四川大学青年教师科研启动基金(2016SCU11047)~~
【分类号】：R722.6;R781.4

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