磨牙缺失对幼年大鼠认知功能的影响
发布时间：2018-08-17 10:45
【摘要】：目的：探讨不同数目磨牙缺失对幼年大鼠认知能力的影响。方法：健康幼年大鼠60只随机分成3、6、9、12颗磨牙缺失组、麻醉对照、正常对照6组。在造模后1周,采用Morris水迷宫系统测试各组大鼠学习记忆能力,每周1次,连续6周。结果：9颗、12颗磨牙缺失组间大鼠游泳平均逃逸潜伏期(the swimming average escape latency,SAEL)无明显差异,但均显著高于其它4组(P0.001)；6颗磨牙缺失组大鼠与3颗磨牙缺失组、麻醉组及正常对照组间SAEL比较有差异(P0.05)；3颗磨牙缺失组、麻醉组及正常对照组组间SAEL比较均无显著性差异(P0.05)。各磨牙缺失组大鼠随着磨牙缺失数目的增多tP/tT值有逐渐下降趋势,9颗、12颗磨牙缺失组间比较无差异(P0.05)与其余各组间比较差异有统计学意义(P0.05),但3颗磨牙缺失组与正常组及麻醉组间tP/tT值无明显差异(P0.05),其他各磨牙缺失组与正常组及麻醉组间tP/tT值均有差异(P0.05)。不同数目磨牙缺失的四组大鼠与麻醉组和正常组在造模前及造模后六周中体重变化组间比较无差异(P0.05)结论：较多数目磨牙缺失会对幼年大鼠的认知能力造成不同程度的损伤,而个别磨牙缺失对大鼠的认知功能无显著性影响。
[Abstract]:Objective: to investigate the effect of different number of molar loss on cognitive ability of young rats. Methods: sixty healthy young rats were randomly divided into 3 groups (n = 12), anesthetic control group (n = 6) and normal control group (n = 6). Morris water maze system was used to test the ability of learning and memory once a week for 6 weeks. Results there was no significant difference in the average escape latency of (the swimming average escape latencies (the swimming average escape latencies) between the two groups, but they were significantly higher than those in the other four groups (P0. 001). There was significant difference in SAEL between anesthetic group and normal control group (P0.05). There was no significant difference in SAEL between anesthetic group and normal control group (P0.05). With the increase of the number of molar missing, the tP/tT value of each molar missing group decreased gradually. There was no significant difference between 9 and 12 molar missing groups (P0.05) compared with the other groups (P0.05), but the three molar missing group and the other groups had no significant difference (P0.05). There was no significant difference in tP/tT value between normal group and anesthetic group (P0.05), but there was significant difference in tP/tT value between other molar missing group and normal group and anesthesia group (P0.05). There was no significant difference in body weight changes between the four groups with different number of molar defects and the anesthetic group and the normal group (P0.05). Conclusion: the cognitive ability of the young rats was damaged by more number of molar loss than that of the anesthetic group and the normal group (P0.05). However, the loss of individual molars had no significant effect on the cognitive function of rats.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R783.4
本文编号：2187360
[Abstract]:Objective: to investigate the effect of different number of molar loss on cognitive ability of young rats. Methods: sixty healthy young rats were randomly divided into 3 groups (n = 12), anesthetic control group (n = 6) and normal control group (n = 6). Morris water maze system was used to test the ability of learning and memory once a week for 6 weeks. Results there was no significant difference in the average escape latency of (the swimming average escape latencies (the swimming average escape latencies) between the two groups, but they were significantly higher than those in the other four groups (P0. 001). There was significant difference in SAEL between anesthetic group and normal control group (P0.05). There was no significant difference in SAEL between anesthetic group and normal control group (P0.05). With the increase of the number of molar missing, the tP/tT value of each molar missing group decreased gradually. There was no significant difference between 9 and 12 molar missing groups (P0.05) compared with the other groups (P0.05), but the three molar missing group and the other groups had no significant difference (P0.05). There was no significant difference in tP/tT value between normal group and anesthetic group (P0.05), but there was significant difference in tP/tT value between other molar missing group and normal group and anesthesia group (P0.05). There was no significant difference in body weight changes between the four groups with different number of molar defects and the anesthetic group and the normal group (P0.05). Conclusion: the cognitive ability of the young rats was damaged by more number of molar loss than that of the anesthetic group and the normal group (P0.05). However, the loss of individual molars had no significant effect on the cognitive function of rats.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R783.4
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