人工合成骨联合釉基质蛋白衍生物（EMD）与单用EMD治疗牙周骨内缺损的疗效比较：meta分析
发布时间：2018-09-04 06:29
【摘要】：目的:评价人工合成骨材料联合釉基质蛋白衍生物(EMD)对比单用EMD治疗牙周骨内缺损的疗效。方法:在Pub Med,the Cochrane Library和EMbase检索相关随机临床对照实验的文献(截止2015年11月)。主要研究指标为探诊深度减少(PPD reduction)、牙周附着获得量(CAL gain)、牙龈退缩增加量(REC increase)和缺损填充获得量(defect fill gain)。结果:最终纳入8篇文献,根据随访时间的长短将纳入的8篇研究分为了短期和长期随访时间两个组。分析的结果显示,在短期随访组(不超过一年),对于探诊深度减少(PPD reduction)、牙龈退缩增加量(REC increase)和缺损填充获得量(defect fill gain)这三个指标,人工合成骨材料联合EMD组对比单用EMD组显示了较好的疗效,且差异有统计学意义(P0.05)。对于牙周附着获得量(CAL gain)这个指标,两组差异没有统计学意义(P=0.17)。在长期随访组(超过一年),对于探诊深度减少(PPD reduction)、牙周附着获得量(CAL gain)和缺损填充获得量(defect fill gain)这三个指标,联合治疗法组显示了较好的疗效,且差异有统计学意义(P0.05)。但对于牙龈退缩增加量(REC increase)这个指标,两组差异没有统计学意义(P=0.05)。结论:考虑到本meta分析研究的局限之处,人工合成骨材料联合EMD对比单用EMD治疗牙周骨内缺损在疗效上的优势不能完全被证实。
[Abstract]:Objective: to evaluate the efficacy of artificial bone material combined with enamel matrix protein derivative (EMD) in the treatment of periodontal intraosseous defect with EMD alone. Methods: literature on randomized controlled trials (as of November 2015) was retrieved from Pub Med,the Cochrane Library and EMbase. Main outcome measures: probing depth reduction of (PPD reduction), periodontal attachment (CAL gain), gingival retraction increased (REC increase) and defect fill acquisition (defect fill gain). Results: 8 articles were included. According to the length of follow-up, the 8 studies were divided into two groups: short and long term follow-up. The results of analysis showed that in the short-term follow-up group (no more than one year), there were three indexes: (REC increase) and (defect fill gain) for probing depth reducing (PPD reduction), gingival retraction. Synthetic bone material combined with EMD group showed a better effect compared with EMD group, and the difference was statistically significant (P0.05). There was no significant difference in periodontal attachment acquisition (CAL gain) between the two groups (P0. 17). In the long-term follow-up group (more than one year), the combined treatment group showed a better effect on the reduction of (PPD reduction), periodontal attachment, (CAL gain) and (defect fill gain), and the difference was statistically significant (P0.05). However, there was no significant difference between the two groups in increasing gingival withdrawal (REC increase) (P0. 05). Conclusion: considering the limitation of this meta analysis, the advantages of artificial bone material combined with EMD in the treatment of periodontal intraosseous defect can not be fully proved compared with the treatment of periodontal intraosseous defect with EMD alone.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R781.4
本文编号：2221287
[Abstract]:Objective: to evaluate the efficacy of artificial bone material combined with enamel matrix protein derivative (EMD) in the treatment of periodontal intraosseous defect with EMD alone. Methods: literature on randomized controlled trials (as of November 2015) was retrieved from Pub Med,the Cochrane Library and EMbase. Main outcome measures: probing depth reduction of (PPD reduction), periodontal attachment (CAL gain), gingival retraction increased (REC increase) and defect fill acquisition (defect fill gain). Results: 8 articles were included. According to the length of follow-up, the 8 studies were divided into two groups: short and long term follow-up. The results of analysis showed that in the short-term follow-up group (no more than one year), there were three indexes: (REC increase) and (defect fill gain) for probing depth reducing (PPD reduction), gingival retraction. Synthetic bone material combined with EMD group showed a better effect compared with EMD group, and the difference was statistically significant (P0.05). There was no significant difference in periodontal attachment acquisition (CAL gain) between the two groups (P0. 17). In the long-term follow-up group (more than one year), the combined treatment group showed a better effect on the reduction of (PPD reduction), periodontal attachment, (CAL gain) and (defect fill gain), and the difference was statistically significant (P0.05). However, there was no significant difference between the two groups in increasing gingival withdrawal (REC increase) (P0. 05). Conclusion: considering the limitation of this meta analysis, the advantages of artificial bone material combined with EMD in the treatment of periodontal intraosseous defect can not be fully proved compared with the treatment of periodontal intraosseous defect with EMD alone.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R781.4
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