不同倒充填材料对显微根尖术后愈合影响的实验研究

发布时间：2018-09-14 10:28

【摘要】：目的:本实验采用动物实验,通过在实验性根尖周病动物模型上完成显微根尖手术,以iRoot BP、MTA和氧化锌作为根尖倒充填材料,术后6个月对比X线片和病理组织切片指标,评估三者的疗效。方法:诱导4只beagle犬的下颌第二、第三、第四前磨牙形成实验性根尖周炎后常规行根管治疗,术后1周行显微根尖外科手术。48个根管随机的分为3组,每组16个根管,分组如下:对照组:氧化锌为倒充填材料实验组1:MTA为倒充填材料实验组2:iRoot BP为倒充填材料术后6个月,拍摄根尖X线片后处死实验动物获得根尖周组织标本,HE染色制作组织病理学切片,评价氧化锌、iRoot BP和MTA的疗效。结果:1、术后6个月的成功率,X线片结果显示,对照组氧化锌为81.2%、iRoot BP组为93.8%、MTA组为93.8%,3种材料间差异无统计学意义;2、组织病理切片结果显示:MTA组和iRoot BP组与氧化锌组相比,炎症程度轻,差异有统计学意义(X~2=17.328,p=0.008,p0.05),iRoot BP组的炎症细胞数目和MTA组之间差异无统计学意义(X~2=0.899,p=0.826,p0.05);MTA组和iRoot BP组的骨质沉积率高于氧化锌组,MTA是3种材料中唯一有硬组织直接沉积的倒充填材料。结论:1、X线片结果显示,作为倒充填材料,氧化锌、MTA和iRoot BP的疗效差异无统计学意义;2、组织病理学结果显示,3种材料均可促进根尖周硬组织的再生,iRoot BP与MTA对根尖周组织的炎症刺激较轻,MTA有最佳的生物相容性。
[Abstract]:Objective: this experiment was carried out on the animal model of experimental periapical disease. IRoot BP,MTA and zinc oxide were used as the apical filling materials, and the X-ray and pathological tissue sections were compared 6 months after operation. Evaluate the efficacy of the three. Methods: the mandibular second, third and fourth premolars of 4 beagle dogs were induced to form experimental periapical periodontitis by routine root canal therapy. 48 root canals were randomly divided into 3 groups with 16 root canals in each group. The groups were as follows: control group: zinc oxide was the reverse filling material 1:MTA was the reverse filling material 2:iRoot BP was the reverse filling material 6 months after operation. Histopathological sections of periapical tissue specimens were obtained by HE staining, and the curative effects of zinc oxide iRoot BP and MTA were evaluated. Results six months after operation, the success rate was 81.2%. The results of X-ray showed that there was no significant difference between the control group (81.2%) and the iRoot group (93.810%). The histopathological results showed that there was no significant difference among the three groups. The results of histopathological sections showed that the ratio of zinc oxide in the two groups was higher than that in the control group (P < 0.05), and that in the control group was higher than that in the control group (P < 0.05). Mild inflammation, There was no significant difference in the number of inflammatory cells between the BP group and the MTA group. The bone deposition rate of the MTA group and iRoot BP group was higher than that of the zinc oxide group. Conclusion the results of the X-ray film showed that it was used as a filling material. The results of histopathology showed that the three materials could promote the regeneration of periapical hard tissue. IRoot BP and MTA had the best biocompatibility to the inflammatory stimulation of periapical tissue.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R781.34

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