选择性激光熔覆制备微孔钛试件及体内实验研究
发布时间：2018-10-07 18:21
【摘要】：目的评估选择性激光熔覆(SLM)成形微孔钛结构对材料生物活性的影响。方法以0~45μm的球形二级钛粉为实验原料,平铺在5 cm×5 cm×0.5 cm的纯钛基板上,在合适的激光参数条件下,制备出孔径范围在150~200μm及200~250μm的两组试件。以大颗粒喷砂酸蚀(SLA)工艺处理的试件为对照,通过动物实验研究,评价材料生物活性。结果场发射扫描电镜观察不同试件表面微孔结构,EDS显示SLA组表面C元素高于SLM组(P=0.037);SLM组试件弹性模量明显降低,接近于人类骨皮质(P0.05);孔径200~250μm试件骨结合率在第8周差异有统计学意义(P=0.028)。结论微孔结构能有效降低试件表面的弹性模量,且孔径范围200~250μm的试件在中期诱导骨形成的能力上更加显著。
[Abstract]:Objective to evaluate the effect of selective laser cladding (SLM) on the bioactivity of microporous titanium. Methods the spherical secondary titanium powder of 0 ~ 45 渭 m was used as the experimental material, and two kinds of samples with pore diameter of 150 ~ 200 渭 m and 200 ~ 250 渭 m were prepared on 5 cm 脳 5 cm 脳 0.5 cm pure titanium substrate under suitable laser parameters. The biological activity of the material was evaluated by animal experiment with the large particle blast acid etching (SLA) process as control. Results Field emission scanning electron microscopy (SEM) showed that the surface C element in SLA group was significantly lower than that in SLM group (P0. 037). It was close to the human bone cortex (P0.05), and the osseous binding rate of the 200m 250 渭 m specimen was significantly different from that of the human bone cortex at the 8th week (P0. 028). Conclusion the micropore structure can effectively reduce the elastic modulus of the specimen surface, and the ability of inducing bone formation in the medium term of the specimen with the pore diameter of 200 ~ 250 渭 m is more remarkable.
【作者单位】： 安徽医科大学第二附属医院口腔科;安徽医学高等专科学校口腔系;
【基金】：安徽省自然科学基金(编号:1508085MH156) 安徽省学术和技术带头人科研活动经费资助项目(编号:2014H030)
【分类号】：R783.1
本文编号：2255207
[Abstract]:Objective to evaluate the effect of selective laser cladding (SLM) on the bioactivity of microporous titanium. Methods the spherical secondary titanium powder of 0 ~ 45 渭 m was used as the experimental material, and two kinds of samples with pore diameter of 150 ~ 200 渭 m and 200 ~ 250 渭 m were prepared on 5 cm 脳 5 cm 脳 0.5 cm pure titanium substrate under suitable laser parameters. The biological activity of the material was evaluated by animal experiment with the large particle blast acid etching (SLA) process as control. Results Field emission scanning electron microscopy (SEM) showed that the surface C element in SLA group was significantly lower than that in SLM group (P0. 037). It was close to the human bone cortex (P0.05), and the osseous binding rate of the 200m 250 渭 m specimen was significantly different from that of the human bone cortex at the 8th week (P0. 028). Conclusion the micropore structure can effectively reduce the elastic modulus of the specimen surface, and the ability of inducing bone formation in the medium term of the specimen with the pore diameter of 200 ~ 250 渭 m is more remarkable.
【作者单位】： 安徽医科大学第二附属医院口腔科;安徽医学高等专科学校口腔系;
【基金】：安徽省自然科学基金(编号:1508085MH156) 安徽省学术和技术带头人科研活动经费资助项目(编号:2014H030)
【分类号】：R783.1
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