低频超声联合曲安奈德对金黄地鼠颊黏膜溃疡愈合的影响
发布时间：2018-10-12 17:34
【摘要】：目的:研究低频超声联合曲安奈德对金黄地鼠实验性口腔溃疡愈合时间,以及溃疡组织中超氧化物歧化酶(superoxide dismutase,SOD)和微量丙二醛(malondialdehyde,MDA)含量的影响。方法:将60只金黄地鼠随机分为5组,1组为基线组(包括正常基线组和溃疡基线组,各6只),另外4组为实验组(低频超声+药物组、单独超声组、单独药物组和空白对照组),每组12只,各组通过"氧自由基损伤法"建立口腔溃疡模型。末次处理24 h后观察溃疡愈合情况,并检测溃疡组织中的SOD活性及MDA含量。采用SPSS 20.0软件包对数据进行统计学分析。结果:低频超声+药物组较单独超声组、单独药物组及空白对照组溃疡愈合时间显著缩短。末次处理24 h后SOD检测结果显示,低频超声+药物组[(2.32±0.30)U/mgprot]较溃疡基线组[(1.48±0.29)U/mgprot]、单独超声组[(1.83±0.15)U/mgprot]、单独药物组[(1.76±0.25)U/mgprot]及空白对照组[(1.71±0.18)U/mgprot]显著增高(P0.05);低频超声+药物组MDA含量[(8.17±0.21)nmol/mgprot]较溃疡基线组[(9.41±0.22)nmol/mgprot]、单独超声组[(9.00±0.44)nmol/mgprot]、单独药物组[(9.04±0.43)nmol/mgprot]及空白对照组[(9.03±0.46)nmol/mgprot]显著降低(P0.05)。溃疡愈合后SOD活性及MDA含量检测显示,低频超声+药物组、单独超声组、单独药物组及空白对照组与正常基线组相比无显著差异(P0.05)。结论:低频超声协同曲安奈德能显著缩短溃疡愈合时间,增加溃疡组织中SOD活性,降低MDA含量,对溃疡的愈合有一定的促进作用。
[Abstract]:Aim: to study the effects of low frequency ultrasound combined with triamcinolone acetonide on healing time of experimental oral ulcer in golden hamsters and the contents of superoxide dismutase (superoxide dismutase,SOD) and malondialdehyde (malondialdehyde,MDA) in ulcer tissues. Methods: sixty golden hamsters were randomly divided into five groups: the baseline group (including normal baseline group and ulcer baseline group, 6 each) and the experimental group (low frequency ultrasound group, single ultrasound group). Oral ulcer model was established by oxygen free radical injury method in 12 rats in each group. The healing of ulcers was observed 24 hours after the last treatment, and the activity of SOD and the content of MDA in the tissues of ulcers were detected. The data were analyzed by SPSS 20.0 software package. Results: the healing time of ulcers in low frequency ultrasound group was significantly shorter than that in single ultrasound group and blank control group. After the last treatment for 24 h, the results of SOD detection showed that, 浣庨瓒呭０ 鑽墿缁刐(2.32卤0.30)U/mgprot]杈冩簝鐤″熀绾跨粍[(1.48卤0.29)U/mgprot],鍗曠嫭瓒呭０缁刐(1.83卤0.15)U/mgprot],鍗曠嫭鑽墿缁刐(1.76卤0.25)U/mgprot]鍙婄┖鐧藉鐓х粍[(1.71卤0.18)U/mgprot]鏄捐憲澧為珮(P0.05);浣庨瓒呭０ 鑽墿缁凪DA鍚噺[(8.17卤0.21)nmol/mgprot]杈冩簝鐤″熀绾跨粍[(9.41卤0.22)nmol/mgprot],鍗曠嫭瓒呭０缁刐(9.00卤0.44)nmol/mgprot],鍗曠嫭鑽墿缁，
本文编号：2267005
[Abstract]:Aim: to study the effects of low frequency ultrasound combined with triamcinolone acetonide on healing time of experimental oral ulcer in golden hamsters and the contents of superoxide dismutase (superoxide dismutase,SOD) and malondialdehyde (malondialdehyde,MDA) in ulcer tissues. Methods: sixty golden hamsters were randomly divided into five groups: the baseline group (including normal baseline group and ulcer baseline group, 6 each) and the experimental group (low frequency ultrasound group, single ultrasound group). Oral ulcer model was established by oxygen free radical injury method in 12 rats in each group. The healing of ulcers was observed 24 hours after the last treatment, and the activity of SOD and the content of MDA in the tissues of ulcers were detected. The data were analyzed by SPSS 20.0 software package. Results: the healing time of ulcers in low frequency ultrasound group was significantly shorter than that in single ultrasound group and blank control group. After the last treatment for 24 h, the results of SOD detection showed that, 浣庨瓒呭０ 鑽墿缁刐(2.32卤0.30)U/mgprot]杈冩簝鐤″熀绾跨粍[(1.48卤0.29)U/mgprot],鍗曠嫭瓒呭０缁刐(1.83卤0.15)U/mgprot],鍗曠嫭鑽墿缁刐(1.76卤0.25)U/mgprot]鍙婄┖鐧藉鐓х粍[(1.71卤0.18)U/mgprot]鏄捐憲澧為珮(P0.05);浣庨瓒呭０ 鑽墿缁凪DA鍚噺[(8.17卤0.21)nmol/mgprot]杈冩簝鐤″熀绾跨粍[(9.41卤0.22)nmol/mgprot],鍗曠嫭瓒呭０缁刐(9.00卤0.44)nmol/mgprot],鍗曠嫭鑽墿缁，
本文编号：2267005
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