消退素D1治疗实验性大鼠牙周炎的研究

发布时间：2018-11-10 18:36

【摘要】：目的:探讨消退素D1(RvD1)对治疗牙周炎的作用。方法:取18只大鼠建立牙周炎模型,按随机化原则均分为实验甲组(100μg/L的RvD1),实验乙组(50μg/L的RvD1)及阴性对照丙组(生理盐水)。所有大鼠均经尾静脉注射给药进行治疗。治疗后不同时间进行临床检查和形态学测量。采用SPSS21.0软件包对数据进行单因素方差分析。结果:治疗后,实验甲组(100μg/L RvD1)中牙周袋深度、牙龈指数、松动度、牙槽骨丧失量均低于阴性对照组(P0.05)。实验乙组(50μg/L RvD1)的以上4个指标虽均低于阴性对照组,但仅牙龈指数和松动度与阴性对照组的差异有统计学意义(P0.05)。两实验组治疗后的牙周袋深度相近(P0.05)。结论:两种浓度的RvD1对实验性大鼠牙周炎有治疗作用;100μg/L的RvD1可阻止实验性大鼠牙周炎的牙槽骨继续破坏。
[Abstract]:Objective: to investigate the effect of vanishing hormone D1 (RvD1) on periodontitis. Methods: periodontitis models were established in 18 rats and were randomly divided into three groups: experimental group A (100 渭 g / L RvD1), experimental group B (50 渭 g / L RvD1) and negative control group C (normal saline). All rats were treated by intravenous injection via tail vein. Clinical examination and morphological measurement were performed at different time after treatment. Single factor analysis of variance (ANOVA) was carried out with SPSS21.0 software package. Results: after treatment, the periodontal bag depth, gingival index, mobility and alveolar bone loss in experimental group A (100 渭 g / L RvD1) were lower than those in control group (P0.05). The above four indexes of experimental group B (50 渭 g / L RvD1) were lower than those of negative control group, but only the gingival index and mobility were significantly different from those of negative control group (P0.05). The periodontal bag depth of the two experimental groups was similar after treatment (P0.05). Conclusion: two concentrations of RvD1 have therapeutic effects on experimental periodontitis in rats, and 100 渭 g / L RvD1 can prevent alveolar bone destruction in experimental periodontitis in rats.
【作者单位】：广西医科大学附属口腔医院牙周黏膜科;广西艾滋病防治研究重点实验室;
【基金】：广西高校科学研究项目(编号:YB2014076) 广西南宁市青秀区科技局科技攻关项目(编号:2015S04)
【分类号】：R781.42

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