人类口腔微生物组学研究:现状、挑战及机遇
发布时间：2018-11-13 16:24
【摘要】：全球超过一半的人口患有口腔疾病,其医护费用与全球十大常见死亡病因的花费相当,而且口腔感染与早产、动脉粥样硬化、肝硬化、糖尿病、阿尔茨海默病等全身性或慢性疾病显著相关,因此,口腔微生物组一直是人类微生物组计划的主要研究对象之一。与人体其他部位比较,口腔微生物组研究具有取样快捷、宿主反应表征方便、干预手段直接有效等特点;同时,超过65%的口腔细菌类群已可培养,诸多代表性菌株的全基因组信息已破译。因此口腔微生物组在菌群内部调控网络及其与宿主互作机制、局部感染对远隔器官的影响机制、以及基于菌群的慢病早期预警等微生物组研究核心科学问题上具备作为模式研究体系与技术示范对象的重要优势。本文在分析口腔微生物组学国际、国内研究现状的基础上,建议尽快启动中国人口腔微生物组计划(China human oral microbiome project,CHOMP),通过产学研协同攻关,开拓基于口腔菌群的口腔及全身系统性疾病的个体化预防、诊断及治疗策略。
[Abstract]:More than half of the world's population suffers from oral diseases, which cost about the same amount of care as the world's top ten common causes of death, and oral infections and preterm birth, atherosclerosis, cirrhosis, diabetes, Systemic or chronic diseases, such as Alzheimer's disease, are significantly associated, so oral microbiology has been one of the main research subjects in the human microbiome program. Compared with other parts of human body, oral microflora research has the characteristics of quick sampling, convenient host reaction characterization and direct and effective intervention. At the same time, more than 65% of oral bacteria groups have been cultured, many representative strains of the whole genome information has been deciphered. Therefore, oral microorganism group in the control network within the flora and its interaction with the host mechanism, local infection on the distant organs of the mechanism, And early warning of slow disease based on microflora has important advantages as a model research system and technology demonstration object on the core scientific issues of microflora research. On the basis of analyzing the international and domestic research status of oral microbiology, this paper suggests to start the Chinese Stomatology Program (China human oral microbiome project,CHOMP) as soon as possible, and to tackle the key problems through the cooperation of industry, education and research. Develop individualized prevention, diagnosis and treatment strategies for oral and systemic diseases based on oral flora.
【作者单位】： 四川大学华西口腔医院口腔疾病研究国家重点实验室;四川大学华西口腔医院牙体牙髓病科;中国科学院青岛生物能源与过程研究所单细胞研究中心;美国加州大学洛杉矶分校牙学院;
【基金】：国家自然科学基金(81430011,31425002,81670978)~~
【分类号】：R780.2
[Abstract]:More than half of the world's population suffers from oral diseases, which cost about the same amount of care as the world's top ten common causes of death, and oral infections and preterm birth, atherosclerosis, cirrhosis, diabetes, Systemic or chronic diseases, such as Alzheimer's disease, are significantly associated, so oral microbiology has been one of the main research subjects in the human microbiome program. Compared with other parts of human body, oral microflora research has the characteristics of quick sampling, convenient host reaction characterization and direct and effective intervention. At the same time, more than 65% of oral bacteria groups have been cultured, many representative strains of the whole genome information has been deciphered. Therefore, oral microorganism group in the control network within the flora and its interaction with the host mechanism, local infection on the distant organs of the mechanism, And early warning of slow disease based on microflora has important advantages as a model research system and technology demonstration object on the core scientific issues of microflora research. On the basis of analyzing the international and domestic research status of oral microbiology, this paper suggests to start the Chinese Stomatology Program (China human oral microbiome project,CHOMP) as soon as possible, and to tackle the key problems through the cooperation of industry, education and research. Develop individualized prevention, diagnosis and treatment strategies for oral and systemic diseases based on oral flora.
【作者单位】： 四川大学华西口腔医院口腔疾病研究国家重点实验室;四川大学华西口腔医院牙体牙髓病科;中国科学院青岛生物能源与过程研究所单细胞研究中心;美国加州大学洛杉矶分校牙学院;
【基金】：国家自然科学基金(81430011,31425002,81670978)~~
【分类号】：R780.2
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