牙周基础治疗对伴2型糖尿病的中、重度牙周炎患者牙周炎症控制、血清炎症指标及代谢水平影响

发布时间：2018-11-16 16:01

【摘要】：目的探讨牙周基础治疗对伴2型糖尿病的中、重度牙周炎患者牙周炎症控制、血清炎症指标以及糖代谢水平的影响。方法将前期临床试验人群中的56例中、重度牙周炎患者(平均临床附着水平3 mm)纳入本研究进行亚组分析,采用重复测量的方差分析比较治疗组和对照组牙周指数(包括平均探诊深度、临床附着水平和探诊出血指数)、超敏C反应蛋白(hsCRP)、糖化血红蛋白(HbA1c)、空腹血糖在基线、1.5个月、3个月、6个月连续4次的变化。结果伴2型糖尿病的中、重度牙周炎患者在牙周治疗后平均探诊深度(F=62.898,P=0.000)、临床附着水平(F=51.263,P=0.000)和探诊出血指数(F=75.164,P=0.000)在治疗后逐渐改善,其中平均探诊深度(t=-2.050,P=0.045)和探诊出血指数(t=-4.538,P=0.000)显著优于对照组;治疗后hsCRP(F=6.391,P=0.010)、HbA1c(F=4.536,P=0.011)、空腹血糖(F=3.073,P=0.031)降低,其中hsCRP显著低于对照组(t=-2.261,P=0.028)。结论牙周基础治疗有助于改善伴2型糖尿病的中、重度牙周炎患者的牙周炎症和血清炎症指标以及糖代谢水平。
[Abstract]:Objective to investigate the effects of periodontal basic therapy on periodontitis control, serum inflammatory indexes and glucose metabolism in patients with moderate and severe periodontitis. Methods 56 patients with severe periodontitis (mean clinical attachment level 3 mm) were included in this study for subgroup analysis. The periodontal index (including the mean probing depth, clinical adhesion level and bleeding index) and the hyper-sensitive C-reactive protein (hsCRP), glycosylated hemoglobin (HbA1c) were compared between the treatment group and the control group by repeated analysis of variance. Fasting blood glucose changes 4 times in baseline, 1.5 months, 3 months, 6 months. Results in patients with moderate and severe periodontitis with type 2 diabetes, the mean probing depth (FV 62.898), the clinical attachment level (FN 51.263) and the diagnostic bleeding index (FN 75.164) were found after periodontal treatment. The average probing depth (t) and bleeding index (t) were significantly higher than those in the control group (P < 0. 0000). The mean probing depth (t) and bleeding index (t) were significantly higher than those in the control group (P < 0. 0000), and the mean probing depth (t) and the bleeding index (t) were significantly higher than those in the control group. After treatment, the levels of hsCRP, HbA1c and fasting blood glucose were decreased, and hsCRP was significantly lower than that in the control group (t = -2.261, P = 0.028). Conclusion periodontal basic therapy can improve periodontitis, serum inflammatory indexes and glucose metabolism in patients with moderate and severe periodontitis with type 2 diabetes.
【作者单位】：广东省口腔医院;南方医科大学附属口腔医院牙周科;
【基金】：科技部“十一五”重点支撑计划基金资助项目(2007BAI-18B02) 广东省科技计划基金资助项目(2010B031600117)
【分类号】：R781.4

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