口腔颌面部成人型横纹肌瘤3例临床病理分析

发布时间：2019-03-12 16:41

【摘要】：目的探讨口腔颌面部成人型横纹肌瘤的临床病理学特征。方法对3例口腔颌面部成人型横纹肌瘤的临床资料、影像学、病理学特征、鉴别诊断、治疗及预后进行回顾性分析,并复习相关文献。结果 3例成人型横纹肌瘤,发病年龄4~83岁;男性2例,女性1例;2例发生于口底,1例发生于舌腹。临床表现为缓慢生长的无痛性包块。眼观:肿块呈结节分叶状,切面棕红色,界限清楚。镜检:肿瘤由排列紧密的嗜酸性或透明的大圆形或多边形细胞构成,胞质内可见横纹及空泡。瘤细胞表达desmin和Myoglobin,灶性表达SMA、Myo D1和S-100蛋白;PAS染色呈阳性,可被淀粉酶消化。结论病理检查是诊断成人型横纹肌瘤的主要方法,胞质中的横纹结构与肌源性蛋白的免疫组化染色是诊断的主要依据。手术完整切除是有效的治疗方法,预后好。
[Abstract]:Objective to investigate the clinicopathological features of adult rhabdomyoma in oral and maxillofacial region. Methods the clinical data, imaging, pathological features, differential diagnosis, treatment and prognosis of 3 cases of oral and maxillofacial adult rhabdomyoma were retrospectively analyzed. Results 3 cases of adult rhabdomyoma with age of 4 to 83 years old, 2 cases of male and 1 case of female, 2 cases in the floor of mouth and 1 case in the abdomen of tongue. Clinical manifestations are slow-growing painless masses. Eye view: the mass is nodular lobulated, brown-red on the sectional plane, and the boundary is clear. Microscopic examination: the tumor consists of closely arranged eosinophilic or transparent large round or polygonal cells with transverse striations and vacuoles seen in the cytoplasm. The tumor cells expressed desmin and Myoglobin, in focal expression of SMA,Myo D1 and Sal 100 protein, and PAS staining was positive and could be digested by amylase. Conclusion pathological examination is the main method for diagnosis of adult rhabdomyoma. The rhabdomyoma structure in cytoplasm and immunohistochemical staining of myogenic protein are the main basis for diagnosis of rhabdomyoma. Complete surgical resection is an effective treatment and has a good prognosis.
【作者单位】：南京大学医学院附属口腔医院/南京市口腔医院口腔病理科;南京大学医学院附属口腔医院/南京市口腔医院口腔颌面外科;
【基金】：江苏省卫生厅面上科研课题(H201344) 江苏省卫计委住院医师规范化培训课题(C2016033)
【分类号】：R739.8

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