0～6岁唇腭裂患儿血液生化指标的变化规律

发布时间：2019-03-20 09:11

【摘要】：目的探索唇腭裂患儿可耐受唇腭裂手术的相对安全生化值,为尽可能多的唇腭裂患儿适时开展手术治疗,保证患儿可以达到序列治疗的最佳效果。方法回顾分析了已安全完成唇腭裂修复手术的985例患儿的术前多项生化值,用多种医学统计分析的方法进行交叉对比。结果患儿的总胆红素、直接胆红素、间接胆红素、白蛋白和肌酐及淋巴细胞和红细胞的95%参考值范围完全包含在标准参考值内,白细胞、血小板、血浆白蛋白和球蛋白的比值(简称白球比)、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)的95%参考值范围较标准参考值高,血红蛋白、总蛋白、球蛋白和尿素95%参考值范围较标准参考值低;唇腭裂患儿各性别组间血红蛋白、总蛋白、白蛋白、球蛋白和尿素的差异有统计学意义,女性患儿的这些数值要普遍高于男性患儿;单纯唇裂患儿的红细胞、血红蛋白、总蛋白、球蛋白、尿素和肌酐均高于单纯腭裂患儿和唇腭裂患儿;唇腭裂患儿的淋巴细胞、总胆红素、直接胆红素、间接胆红素、ALT和AST均高于单纯腭裂患儿和单纯唇裂患儿。结论唇腭裂患儿的白细胞、血小板、淋巴细胞、白球比、ALT和AST可能较标准参考值偏高,医生在作术前评估时,可以参考本研究结果,作为开展唇腭裂手术的相对安全指标,以避免错过患儿的最佳手术期,但同时也要更加留意其相关风险性。
[Abstract]:Objective To explore the relative safety and biochemical value of lip-cleft operation in children with cleft lip, and to carry out the operation treatment in time to ensure that the children can achieve the best effect of sequence treatment. Methods The pre-operative biochemical values of 985 children with safe completion of the cleft lip repair operation were analyzed and the cross-correlation was carried out with a variety of methods of medical statistical analysis. Results The 95% reference range of total bilirubin, direct bilirubin, indirect bilirubin, albumin and myoglobin, and lymphocytes and red blood cells in the children was completely included in the standard reference value, and the ratio of white blood cells, platelets, plasma albumin and globulin (the white ball ratio), The reference value of the 95% reference value of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) is higher than that of the standard reference value, and the reference value of hemoglobin, total protein, globulin and urea is lower than that of the standard reference value; and the hemoglobin and total protein in each sex group of the children with the cleft lip are less than that of the standard reference value; The difference of albumin, globulin and urea is of statistical significance. The numbers of the female children are higher than that of male children. The red blood cell, hemoglobin, total protein, globulin, urea and myoglobin in the children with simple cleft lip are higher than those of the children with simple cleft lip and cleft lip; The lymphocytes, total bilirubin, direct bilirubin, indirect bilirubin, ALT and AST of the children with cleft lip were higher than those of children with simple cleft lip and simple cleft lip. Conclusion The white blood cell, the platelet, the lymphocyte, the white ball ratio, the ALT and the AST of the children with cleft lip may be higher than the standard reference value. But at the same time, pay more attention to its associated risks.
【作者单位】：口腔疾病研究国家重点实验室国家口腔疾病临床研究中心四川大学华西口腔医院唇腭裂外科;
【分类号】：R782.2

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