不同矫治力作用下白细胞介素-1β对牙周组织改建的影响

发布时间：2019-05-11 21:50

【摘要】：目的观察不同矫治力作用前后正畸牙龈沟液中白细胞介素(IL)-1β的表达变化,探讨IL-1β在正畸牙移动过程中对牙周组织改建的影响。方法选择24例拔除4颗第一双尖牙矫治青少年患者,年龄11.3~15.2岁,平均(13.4±1.9)岁,牙列排齐整平后,分别施加100、150、250 g的初始力远中移动尖牙。左侧上颌尖牙为观察组,A组加力100 g,B组加力150 g,C组加力250 g。右侧上颌尖牙为对照组,不加力。分别在加力前、加力后1、3、7、14、28 d收集两组牙远中临面处的龈沟液。用酶联免疫方法测定龈沟液中IL-1β的含量。结果 A组和B组的IL-1β浓度变化规律一致:在加力后开始增高,3 d时达到高峰,后开始下降,14 d恢复至加力前水平。C组加力后1 d IL-1β浓度缓慢升高,3、7、14 d保持在大致同一水平,28 d恢复至加力前水平。A组、对照组IL-1β的平均浓度低于B组,差异有统计学意义(P0.05),而对照组和C组IL-1β的浓度前后未出现明显变化,两者比较差异无统计学意义(P0.05)。结论不同矫治力作用下龈沟液内IL-1β表达变化不同,提示适当的正畸力可引发牙周组织发生正常的生理性改建,过大正畸力的作用可造成牙周组织损伤,影响正畸治疗效果。
[Abstract]:Aim to observe the expression of interleukin-1 尾 (IL)-1 尾) in gingival crevicular fluid before and after orthodontic tooth movement, and to investigate the effect of IL-1 尾 on periodontal tissue remodeling during orthodontic tooth movement. Methods 24 patients (11.3 卤15.2 years old, mean (13.4 卤1.9) years) with 4 first bicuspid teeth were selected. After the dentition was leveled, the initial force of 100150250 g was applied to the distal middle movement of the canines respectively. The left maxillary fangs were treated with 100 g in group A, 150 g in group B and 250 g in group C. The right maxillary canines were the control group, no force was added. The gingival crevicular fluid (GCF) of the two groups was collected before and 1, 3, 7, 14, 28 days before and 1, 3, 7, 14, 28, respectively. The content of IL-1 尾 in gingival crevicular fluid was determined by enzyme linked immunosorbent assay (Elisa). Results the changes of IL-1 尾 concentration in group A and group B were the same as those in group B: the concentration of IL-1 尾 began to increase after loading, reached the peak at 3 d, decreased at 3 d, and returned to the level of pre-loading on 14 d. In group C, the concentration of TGF 尾 increased slowly on the 1st day after loading, and increased slowly at 3, 7, 3, 7 days after loading. The average concentration of IL-1 尾 in group A was lower than that in group B, and the difference was statistically significant (P 0.05). However, there was no significant change in the concentration of IL-1 尾 between the control group and group C before and after, and there was no significant difference between the two groups (P 0.05). Conclusion the changes of IL-1 尾 expression in gingival crevicular fluid under different orthodontic forces are different, suggesting that proper orthodontic force can induce normal physiological remodeling of periodontal tissue, and excessive orthodontic force can cause periodontal tissue damage and affect the effect of orthodontic treatment.
【作者单位】：承德医学院附属医院口腔科;
【基金】：河北省承德市科学技术研究与发展计划项目(编号:20122157)
【分类号】：R783.5

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