原发性舍格伦综合征患者Th22细胞及其细胞因子IL-22的表达及意义

发布时间：2019-05-18 02:38

【摘要】：目的探讨Th22细胞及其细胞因子白细胞介素22(IL-22)在原发性舍格伦综合征(p SS)患者外周血中的表达及临床意义。方法 p SS患者根据唾液腺受累程度分为轻、中、重度患者。健康成人作为对照组。检测Th22细胞及其细胞因子IL-22在轻、中、重度p SS患者和健康对照组外周血中的表达。结果 p SS患者外周血中Th22细胞及细胞因子IL-22表达明显高于健康对照组(P0.05)。而且患者病情越严重,外周血中Th22细胞及细胞因子IL-22水平越高:重度组高于中度组(P0.05),中度组高于轻度组(P0.05)。结论 p SS患者外周血中Th22及其细胞因子IL-22较健康对照组明显升高,而且病情越严重,Th22及其细胞因子IL-22水平越高。因此,检测外周血中Th22及其细胞因子IL-22水平有可能成为判断p SS病情严重程度的指标,并为治疗提供新的治疗靶点。
[Abstract]:Objective to investigate the expression and clinical significance of Th22 cells and their cytokine IL-22 (IL-22) in peripheral blood of patients with primary Shergren syndrome (p SS). Methods p SS patients were divided into mild, moderate and severe patients according to the degree of salivary gland involvement. Healthy adults served as control group. The expression of Th22 cells and its cytokine IL-22 in peripheral blood of mild, moderate and severe p-SS patients and healthy controls were detected. Results the expression of Th22 cells and cytokine IL-22 in peripheral blood of p SS patients was significantly higher than that of healthy controls (P 0.05). And the more serious the patient's condition, the higher the level of Th22 cells and cytokines IL-22 in peripheral blood: the severe group was higher than the moderate group (P 0.05), and the moderate group was higher than the mild group (P 0.05). Conclusion the level of Th22 and its cytokine IL-22 in peripheral blood of p SS patients is significantly higher than that of healthy control group, and the more serious the disease is, the higher the level of Th22 and its cytokine IL-22 is. Therefore, the detection of Th22 and its cytokine IL-22 in peripheral blood may be an index to judge the severity of p-SS and provide a new therapeutic target for treatment.
【作者单位】：大庆油田总医院口腔颌面外科;佳木斯大学口腔医学院口腔颌面外科;中国医科大学附属盛京医院口腔科;
【基金】：辽宁省科学技术计划(2011010215-404)
【分类号】：R781.7

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