自体浓缩生长因子膜在口腔黏膜组织缺损中的应用

发布时间：2019-05-18 05:45

【摘要】：目的本研究利用自体浓缩生长因子(CGF)膜修复口腔黏膜组织缺损,观察、探讨其促进软组织愈合、减少瘢痕的效果,评价CGF膜应用于口腔黏膜组织缺损修复的临床意义,并为口腔黏膜组织缺损的治疗提供新的思路和方法。方法选择并收集宁夏医科大学总医院口腔颌面外科病房2015年3月至2016年11月收治的因手术切除造成口腔黏膜组织缺损的患者,随机分组,实验组利用自体CGF膜修复缺损创面后碘仿纱条敷料反包扎固定;对照组直接运用碘仿纱条敷料反包扎覆盖创面进行同期对照。随访术后1周、2周、3周、1月、2月、3月口腔黏膜缺损区生长情况,拍摄照片,运用Image-Pro Plus(IPP)图像分析软件计算缺损区域愈合面积率,记录创面愈合时间,采用视觉模拟量表(VAS)测评患者的主观感受,用温哥华瘢痕量表(VSS)中文版测评术后3月瘢痕形成情况,并进行统计分析。结果自2015年3月至2016年11月收集的口腔黏膜组织缺损患者42例,失访3例,39例纳入研究,随机分为实验组19例,对照组20例。1.对实验组与对照组术后2周、3周、1月时创面愈合率进行统计学分析,差异具有统计学意义。2.对实验组与对照组术后1周、2周、3周、1月时VAS评分进行统计学分析,显示均有统计学差异。3.对实验组与对照组术后3月时VSS评分进行统计学分析,显示差异具有统计学意义。结论1.CGF膜可以用于口腔黏膜组织缺损的修复。2.应用CGF膜修复口腔黏膜组织缺损创面,可缩短创面愈合时间、减轻术后不适感、减少术后瘢痕的形成。3.CGF膜取自自体静脉血,获取方便快捷,适宜临床推广。
[Abstract]:Objective to observe the effect of autologous concentrated growth factor (CGF) membrane on repairing oral mucous membrane tissue defect, to explore the effect of promoting soft tissue healing and reducing scar, and to evaluate the clinical significance of CGF membrane in the repair of oral mucous membrane tissue defect. It also provides a new idea and method for the treatment of oral mucous membrane tissue defect. Methods from March 2015 to November 2016, patients with oral and maxillofacial defects caused by surgical resection were randomly divided into two groups. In the experimental group, iodoform gauze dressing was fixed with iodoform gauze dressing after repairing the defect wound with autologous CGF membrane. The control group was directly covered with iodoform gauze dressing for the same period. 1 week, 2 weeks, 3 weeks, 1 month, 2 months and 3 months after follow-up, the growth of oral mucous membrane defect area was taken, the healing area rate of defect area was calculated by Image-Pro Plus (IPP) image analysis software, and the wound healing time was recorded. The subjective feelings of the patients were measured by visual simulation scale (VAS), and the scar formation was evaluated by Vancouver scar scale (VSS) in Chinese version, and the statistical analysis was carried out. Results from March 2015 to November 2016, 42 patients with oral mucosal tissue defect were collected, 3 of them lost follow-up, and 39 of them were included in the study. They were randomly divided into experimental group (n = 19) and control group (n = 20). The wound healing rate of the experimental group and the control group at 2 weeks, 3 weeks and 1 month after operation were statistically analyzed, and the difference was statistically significant. 2. The VAS scores of the experimental group and the control group at 1 week, 2 weeks, 3 weeks and 1 month after operation were statistically analyzed, and there was significant difference between the experimental group and the control group at 1 week, 2 weeks, 3 weeks and 1 month after operation. The VSS score of the experimental group and the control group at 3 months after operation was statistically analyzed, and the difference was statistically significant. Conclusion 1.CGF membrane can be used to repair oral mucous membrane defects. 2. The application of CGF membrane to repair oral mucous membrane defect can shorten the wound healing time, reduce the discomfort after operation and reduce the formation of scar after operation. 3. CGF membrane is taken from autologous venous blood, which is convenient and rapid, and is suitable for clinical promotion.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R782

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