评价富血小板纤维蛋白单独用于上颌窦提升种植骨再生的效果

发布时间：2019-05-23 04:46

【摘要】：背景:富血小板纤维蛋白作为一种富含生长因子、纤维蛋白的自体血液浓缩物,具有促进组织再生的功效。通常与自体或异体骨粉混合应用于口腔颌面部骨缺损的修复,促进骨再生,但其单独作为上颌窦提升植骨材料的成骨效果还有争议。目的:通过建立上颌窦提升同期种植模型,单独使用富血小板纤维蛋白作为骨移植材料,观察评价种植体周围骨再生的效果。方法:12-18个月龄的健康成年杂种犬12只,随机分为富血小板纤维蛋白组、自体骨组、自体血液组,每组4只。拔除双侧上颌第一磨牙,12周后行上颌窦外提升同期种植术。3组犬的上颌窦内分别植入同等体积富血小板纤维蛋白、自体骨屑、自体血液。植入后12周取材,通过大体观察、影像学及组织学分析评价骨再生效果。结果与结论:(1)所有种植体周围都有不同程度的新骨生成,新生骨与窦底骨质相连接,种植体尖端无骨形成;(2)新骨高度:富血小板纤维蛋白组为(3.135±0.288)mm,自体骨组为(3.218±0.345)mm,自体血液组为(1.898±0.157)mm,富血小板纤维蛋白组和自体血液组,自体骨组和自体血液组之间的新骨高度差异有显著性意义(P0.05);(3)新骨密度:富血小板纤维蛋白组为(65.06±5.88)g/cm3,自体骨组为(75.34±8.18)g/cm3,自体血液组为(56.92±4.95)g/cm3。富血小板纤维蛋白组和自体骨组,自体骨组和自体血液组,富血小板纤维蛋白组和自体血液组之间的新骨密度差异有显著性意义(P0.05);(4)结果表明,将富血小板纤维蛋白单独应用于上颌窦提升种植中,可以促进种植体周围的新骨形成,但新骨的形成量有限。
[Abstract]:Background: platelet-rich fibrin, as a kind of autologous blood concentrate rich in growth factor and fibrin, has the effect of promoting tissue regeneration. It is usually mixed with autologous or allogenic bone powder to repair oral and maxillofacial bone defects and promote bone regeneration, but its osteogenic effect as maxillary sinus lifting bone grafting material is controversial. Objective: to observe and evaluate the effect of bone regeneration around maxillary sinus by establishing maxillary sinus lifting simultaneous implantation model and using platelet-rich fibrin as bone transplantation material alone. Methods: twelve healthy adult mongrel dogs aged 12 months were randomly divided into platelet rich fibrin group, autologous bone group and autologous blood group with 4 dogs in each group. Bilateral maxillary first molars were removed and external maxillary sinus lifting and simultaneous implantation were performed 12 weeks later. The same volume of platelet-rich fibrin, autologous bone debris and autologous blood were implanted into the maxillary sinus of the three groups. The bone regeneration effect was evaluated by gross observation, imaging and histology analysis 12 weeks after implantation. Results and conclusion: (1) there were different degrees of new bone formation around all the implants. the new bone was connected with the bone at the floor of the sinus, and there was no bone formation at the tip of the implantation. (2) the height of new bone: the platelet-rich fibrin group was (3.135 卤0.288) mm, the autologous bone group was (3.218 卤0.345) mm, the platelet-rich fibrin group was (1.898 卤0.157) mm, platelet-rich fibrin group, and the autologous blood group was (1.898 卤0.157) platelet-rich fibrin group. There was significant difference in the height of new bone between autologous bone group and autologous blood group (P 0.05). (3) New bone mineral density: platelet-rich fibrin group was (65.06 卤5.88) g / cm ~ 3, autologous bone group was (75.34 卤8.18) g / cm ~ 3, autologous blood group was (56.92 卤4.95) g 路cm ~ 3. There were significant differences in new bone mineral density between platelet-rich fibrin group and autologous bone group, autologous bone group and autologous blood group, platelet-rich fibrin group and autologous blood group (P 0.05). (4) the results showed that the application of platelet-rich fibrin alone in maxillary sinus lifting implantation could promote the formation of new bone around the implantation, but the amount of new bone formation was limited.
【作者单位】：大连医科大学口腔医学院口腔颌面外科;大连医科大学附属口腔医院口腔颌面外科;
【基金】：辽宁省自然科学基金(2015010313-301)~~
【分类号】：R783.6

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