一种新型含稳定亚锡-氟化钠牙膏的菌斑渗透率和脂多糖中和效率的临床评价
发布时间：2019-06-02 16:21
【摘要】：目的:评价一种新型含亚锡-氟化钠牙膏中亚锡离子的菌斑渗透率和脂多糖(LPS,内毒素)中和效率。方法:采用随机、对照、单盲的原位临床试验。分为PBS、新型亚锡-氟化钠牙膏(EXP)和市售亚锡-氟化钠牙膏(MKD)3组。用荧光染料、荧光探针及激光共聚焦荧光共定位方法分析。结果:EXP组亚锡离子菌斑渗透率和LPS中和效率显著优于MKD和PBS组(P0.05)。EXP组亚锡离子和结合态LPS的荧光存在96.52%的空间共定位。结论:新型含亚锡-氟化钠牙膏中的亚锡离子能渗入菌斑内部并中和LPS。
[Abstract]:Aim: to evaluate the plaque permeability and lipopolysaccharide (LPS, endotoxin) neutralization efficiency of a new stannous sodium fluoride toothpaste containing stannous ion. Methods: a random, controlled, single blind in situ clinical trial was conducted. It was divided into three groups: PBS, new stannous sodium fluoride toothpaste (EXP) and stannous sodium fluoride toothpaste (MKD). The results were analyzed by fluorescence dye, fluorescence probe and laser confocal fluorescence localization method. Results: the plaque permeability and LPS neutralization efficiency of stannous ion in EXP group were significantly better than those in MKD and PBS group (P 0.05. The fluorescence of stannous ion and bound LPS in). EXP group was 96.52% co-localization. Conclusion: the stannous ion in the new stannous sodium fluoride toothpaste can infiltrate into the plaque and neutralize LPS..
【作者单位】： 武汉大学口腔医学院 口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室;北京宝洁技术有限公司;武汉大学口腔医学院牙周科;Procter
【分类号】：R78
本文编号：2491259
[Abstract]:Aim: to evaluate the plaque permeability and lipopolysaccharide (LPS, endotoxin) neutralization efficiency of a new stannous sodium fluoride toothpaste containing stannous ion. Methods: a random, controlled, single blind in situ clinical trial was conducted. It was divided into three groups: PBS, new stannous sodium fluoride toothpaste (EXP) and stannous sodium fluoride toothpaste (MKD). The results were analyzed by fluorescence dye, fluorescence probe and laser confocal fluorescence localization method. Results: the plaque permeability and LPS neutralization efficiency of stannous ion in EXP group were significantly better than those in MKD and PBS group (P 0.05. The fluorescence of stannous ion and bound LPS in). EXP group was 96.52% co-localization. Conclusion: the stannous ion in the new stannous sodium fluoride toothpaste can infiltrate into the plaque and neutralize LPS..
【作者单位】： 武汉大学口腔医学院 口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室;北京宝洁技术有限公司;武汉大学口腔医学院牙周科;Procter
【分类号】：R78
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