牙龈卟啉单胞菌相关牙周炎疫苗有效免疫原及其途径和佐剂

发布时间：2019-06-19 22:03

【摘要】：牙龈卟啉单胞菌细胞表面的多种抗原可诱导机体产生保护性免疫应答,阻止牙龈卟啉单胞菌定植和感染,因此选择合适的牙龈卟啉单胞菌有效免疫原作为疫苗候选抗原来防治牙周炎具有重要的研究价值。牙龈卟啉单胞菌细胞膜上的菌毛蛋白、牙龈蛋白、血凝蛋白、外膜蛋白、被膜蛋白和热休克蛋白等多种表面抗原,皆有可能成为牙龈卟啉单胞菌相关牙周炎疫苗有效免疫原。牙周炎疫苗研究常用的免疫途径有腺体免疫、黏膜免疫、皮下接种和肌肉注射等,学者们普遍认为,黏膜免疫应该成为牙周炎疫苗免疫的主要方式。另外,牙周炎疫苗中使用佐剂可刺激机体产生免疫应答,增强抗原免疫原性。在未来的牙周炎疫苗研究中,应该结合牙龈卟啉单胞菌的多种特异性抗原找到各血清型牙龈卟啉单胞菌共同的抗原决定簇,结合其他牙周致病菌的有效免疫原及选择最有效的免疫途径和使用抗原呈递和佐剂系统。
[Abstract]:A variety of antigens on the cell surface of Porphyromonas gums can induce protective immune response and prevent Porphyromonas gums from colonization and infection. Therefore, it is of great value to select the appropriate effective immunogen of Porphyromonas gums as vaccine candidate antigen for the prevention and treatment of periodontitis. Many surface antigens such as fimbriin, gum protein, hemagglutinin, outer membrane protein, envelope protein and heat shock protein on the cell membrane of Porphyromonas gums may become effective immunogens of Porphyromonas gums related periodontitis vaccine. The commonly used immune pathways in periodontitis vaccine research are gland immunization, mucous membrane immunization, subcutaneous vaccination and intramuscular injection. Scholars generally believe that mucous membrane immunization should be the main way of periodontitis vaccine immunization. In addition, the use of adjuvants in periodontitis vaccine can stimulate the body to produce immune response and enhance antigen immunogenicity. In the future research of periodontitis vaccine, the common antigenic determinant of Porphyromonas gums should be found in combination with various specific antigens of Porphyromonas gums, the effective immunogen of other periodontal pathogenic bacteria should be combined with the most effective immune pathway, and the antigen presentation and adjuvant system should be used.
【作者单位】：口腔疾病研究国家重点实验室华西口腔医院牙周科(四川大学);
【基金】：国家自然科学基金(81371150)
【分类号】：R781.4

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