抗菌药物应用与医院感染的相关性调查分析

发布时间：2018-03-20 19:52

本文选题：抗菌药物　切入点：医院感染　出处：《中华医院感染学杂志》2014年07期 　论文类型：期刊论文

【摘要】：目的调查医院抗菌药物的临床应用情况,并探讨其与医院感染的相关性,为抗菌药物的临床合理应用提供指导依据。方法对2010-2012年医院6 147例住院患者临床资料的抗菌药物使用及医院感染情况进行回顾性调查统计与分析,计数资料以百分率表示,采用χ2检验及相关性检验分析。结果 6 147例患者应用抗菌药物5 496例,抗菌药物使用率为89.41%,发生医院感染154例,感染率为2.51%;2010-2012年抗菌药物使用率分别为92.74%、91.27%、84.93%,2010-2012年医院感染率分别为2.74%、2.63%、2.19%,二者呈显著正相关性(r=0.9 999,P0.05);儿科的抗菌药物使用率和医院感染率均为最高,分别是93.87%、4.23%;抗菌药物使用中预防用药、治疗用药、预防+治疗使用率分别为61.59%、36.57%、1.84%,相应的医院感染率分别为1.83%、3.88%、1.98%;一、二、三联使用率分别为55.42%、43.50%、1.07%,相应的医院感染率分别为1.67%、3.47%、13.56%。结论抗菌药物应用是医院感染发生的重要相关因素,应加强抗菌药物的合理应用,降低医院感染率。
[Abstract]:Objective to investigate the clinical application of antimicrobial agents in hospitals and to explore the correlation between them and nosocomial infections. Methods the clinical data of 6 147 inpatients in hospital from 2010 to 2012 were retrospectively investigated and analyzed in terms of the use of antibiotics and nosocomial infection. The counting data were expressed as percentage. Results among 6 147 patients, 5 496 cases were treated with antimicrobial agents, the utilization rate of antibiotics was 89.41, and 154 cases of nosocomial infection occurred. The infection rate in 2010-2012 was 92.741.27 and 84.93and the nosocomial infection rate in 2010-2012 was 2.7443 and 2.19, respectively. There was a significant positive correlation between the two rates. The antimicrobial use rate and nosocomial infection rate in pediatrics were the highest, 93.877.43 and 93.874.23, respectively. The utilization rate of treatment and preventive treatment were 61.59 and 36.570.The corresponding nosocomial infection rates were 1.83 and 3.881.98 respectively; the first, second, and triple usage rates were 55.42 and 43.50 respectively, and the corresponding nosocomial infection rates were 1.673.4713.566.Conclusion Antimicrobial use is an important related factor in the occurrence of nosocomial infection, and the corresponding rate of nosocomial infection is 1.673.4713.560.Conclusion Antimicrobial use is an important related factor in the occurrence of nosocomial infection. The rational application of antimicrobial agents should be strengthened to reduce the nosocomial infection rate.
【作者单位】：宁波市妇女儿童医院药剂科;
【基金】：浙江省药学会医院药学科研基金项目(2012ZYY27)
【分类号】：R181.3

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