北京市二价脊髓灰质炎减毒活疫苗引入前后不同基础免疫程序效果和疫苗效价分析
发布时间：2018-08-20 07:56
【摘要】：目的了解二价脊髓灰质炎(脊灰)减毒活疫苗(b OPV)引入前后北京市2014年和2016年不同基础免疫程序免疫效果和疫苗效价。方法 2014年和2016年脊灰疫苗基础免疫程序分别为3剂三价脊灰减毒活疫苗(t OPV)全程免疫和1剂脊灰灭活疫苗(IPV)与2剂二价脊灰减毒活疫苗(b OPV)序贯免疫,分别在北京市两个区选择完成基础免疫后4-8周的婴儿,采集血标本以检测脊灰病毒中和抗体,同时采集不同疫苗储运环节的疫苗标本以检测疫苗效价。结果 2014年和2016年分别调查儿童72人和68人。2014年基础免疫后Ⅰ、Ⅲ型脊灰病毒中和抗体阳性率分别为98.61%和100%,抗体滴度(1∶)[中位数(四分位数间距)]分别为1 536(1 024-1 536)、1 536(512-1 536);2016年基础免疫后Ⅰ型、Ⅲ型脊灰病毒中和抗体阳性率均为100%,抗体滴度(1∶)分别为1 024(512-1 536)、1 536(1 024-1 536)。2014年和2016年Ⅰ、Ⅲ型脊灰病毒中和抗体分布均有显著性差异(Ⅰ型:χ2=8.77,P=0.038;Ⅲ型:χ2=16.76,P=0.001)。2014年t OPV的平均效价为6.1±0.1Lg CCID50/剂,2016年b OPV的平均效价为6.9±0.2Lg CCID50/剂(t=-7.76,P0.001)。结论新疫苗b OPV引入后,IPV-b OPV序贯免疫程序的基础免疫效果与引入前的t OPV全程和IPV-t OPV序贯免疫程序效果一样好;疫苗储运各环节疫苗效价均合格,冷链运转良好。
[Abstract]:Objective to investigate the immune efficacy and vaccine titer of divalent live attenuated poliomyelitis vaccine (b OPV) in 2014 and 2016 in Beijing. Methods the basic immunization procedures of polio vaccine in 2014 and 2016 were 3 doses of trivalent live attenuated poliovirus vaccine (t OPV), 1 dose of poliomyelitis inactivated vaccine (IPV) and 2 doses of divalent live attenuated vaccine (b OPV) sequential immunization. Infants aged 4-8 weeks after basic immunization were selected in two districts of Beijing. Blood samples were collected to detect neutralizing antibodies against poliovirus and vaccine samples from different vaccine storage and transportation links were collected to detect vaccine titer. Results 72 and 68 children were investigated in 2014 and 2016, respectively. The positive rates of neutralizing antibodies against poliovirus type 鈪，
本文编号：2192942
[Abstract]:Objective to investigate the immune efficacy and vaccine titer of divalent live attenuated poliomyelitis vaccine (b OPV) in 2014 and 2016 in Beijing. Methods the basic immunization procedures of polio vaccine in 2014 and 2016 were 3 doses of trivalent live attenuated poliovirus vaccine (t OPV), 1 dose of poliomyelitis inactivated vaccine (IPV) and 2 doses of divalent live attenuated vaccine (b OPV) sequential immunization. Infants aged 4-8 weeks after basic immunization were selected in two districts of Beijing. Blood samples were collected to detect neutralizing antibodies against poliovirus and vaccine samples from different vaccine storage and transportation links were collected to detect vaccine titer. Results 72 and 68 children were investigated in 2014 and 2016, respectively. The positive rates of neutralizing antibodies against poliovirus type 鈪，
本文编号：2192942
本文链接：https://www.wllwen.com/yixuelunwen/liuxingb/2192942.html
