右美托咪定复合丙泊酚对单肺通气时肺内分流及氧分压的影响

发布时间：2018-02-23 00:47

本文关键词： 右美托咪定肺内分流氧分压单肺通气　出处：《实用医学杂志》2015年21期 　论文类型：期刊论文

【摘要】：目的:观察右美托咪定对单肺通气时肺内分流及氧分压的影响。方法:择期开胸的肺手术患者,随机均分为右美托咪定(Dex组)和生理盐水组(Sal组)。麻醉诱导后Dex组泵注右美托咪定,Sal组泵注生理盐水。分别在双肺通气、单肺通气后10、20、30、40、50、60 min和术毕同时抽取动脉和中心静脉血行血气分析,计算肺内分流,同时记录MAP、HR、SPO_2、Ppeak、Pplat、VT、PICO_2和BIS。记录丙泊酚、舒芬太尼、右美托咪定、麻黄碱和阿托品等用量。结果MAP、HR、SpO_2、Ppeak、Pplat、VT、PICO_2和BIS在各时间点,两组比较差异无统计学意义。术毕,Dex组肺内分流大于Sal组,氧分压低于Sal组,差异有统计学意义。结论:丙泊酚复合右美托咪定单肺通气时增加肺内分流,降低氧分压,临床应重视,需进一步的观察与研究。
[Abstract]:Objective: to observe the effect of dexmetomidine on intrapulmonary shunt and partial pressure of oxygen during single lung ventilation. After anesthesia induction, Dex group was injected with dexmetomidine and dexmetomidine Sal group, and were ventilated in both lungs. After one-lung ventilation, arterial and central venous blood samples were taken at the same time for blood gas analysis after one-lung ventilation for 10 ~ 20 ~ 30 ~ 40 ~ 50 ~ 60 min and then to calculate intrapulmonary shunt. Meanwhile, map HRHR-SPO _ (2) -P _ (2) P _ (peak-Pplatplatus) V _ T _ (PICO _ 2) and BiS were recorded, and propofol, sufentanil, dexmetidine were recorded. Results there was no significant difference between the two groups in the dosage of ephedrine and atropine. Results at each time point, there was no significant difference between the two groups. The intrapulmonary shunt was higher in the Dex group than in the Sal group, and the partial pressure of oxygen was lower than that in the Sal group. Conclusion: propofol combined with dexmetomi order can increase intrapulmonary shunt and decrease oxygen partial pressure, which should be paid more attention to in clinic and need further observation and study.
【作者单位】：苏州大学附属第一医院麻醉科;无锡市人民医院麻醉科;
【分类号】：R614

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