舒芬太尼联合咪达唑仑对骨折手术患者的镇痛效果

发布时间：2018-03-01 21:46

本文关键词： 舒芬太尼咪达唑仑骨折手术椎管内麻醉炎症因子　出处：《中国医药导刊》2016年11期 　论文类型：期刊论文

【摘要】：目的:探讨舒芬太尼联合咪达唑仑对骨折手术患者的镇痛效果。方法:130例患者随机分为观察组65例和对照组65例,对照组采用芬太尼联合咪达唑仑椎管内麻醉,观察组给予舒芬太尼联合咪达唑仑椎管内麻醉;比较两组患者麻醉各时段RR、HR、Sp O2、MAP变化,检测各时段患者血清IL-6、TNF-α变化水平,麻醉期间镇静效果和术后镇痛效果。结果:两组患者麻醉后RR、HR、Sp O2、MAP均呈降低趋势,观察组T1、T2时段RR显著高于同时段对照组(P0.05)。麻醉后两组患者Ramsay评分均呈上升趋势,观察组Ramsay评分显著高于同时段对照组(P0.05)。从术后6h两组患者VAS评分逐渐呈上升趋势,观察组VAS评分显著低于同时段对照组(P0.05)。从T0时段开始两组患者血清IL-6、TNF-α均呈升高趋势,在T2、T3、T4时段观察组血清水平显著低于同时段对照组(P0.05)。结论:舒芬太尼联合咪达唑仑应用于骨折手术椎管内麻醉能够显著增强术后镇痛效果。
[Abstract]:Objective: to investigate the analgesic effect of sufentanil combined with midazolam on patients undergoing fracture surgery. Methods: 130 patients were randomly divided into observation group (n = 65) and control group (n = 65). The observation group was treated with sufentanil combined with midazolam intraspinal anesthesia, the changes of RRN HRP O 2 map and the level of serum IL-6 TNF- 伪 in each period of anesthesia were compared between the two groups. Results: after anesthesia, the RR of RRX HRSpO2MAP in the observation group was significantly higher than that of the control group in the same period (P 0.05). The Ramsay score of the two groups increased after anesthesia, and the RR of the observation group was significantly higher than that of the control group in the same time period (P 0.05). The Ramsay score of the observation group was significantly higher than that of the control group in the same period (P 0.05). The VAS score of the two groups gradually increased from 6 hours after operation, and the VAS score of the observation group was significantly lower than that of the control group in the same period (P 0.05). The serum level in the observation group was significantly lower than that in the control group at the same time. Conclusion: sufentanil combined with midazolam in spinal canal anesthesia for fracture surgery can significantly enhance the postoperative analgesic effect.
【作者单位】：江苏省徐州市中心医院麻醉科;
【分类号】：R614

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