宁夏回族人群雌激素受体基因多态性及与血脂的关联性

发布时间：2018-01-06 14:35

本文关键词：宁夏回族人群雌激素受体基因多态性及与血脂的关联性　出处：《西安交通大学学报(医学版)》2016年03期 　论文类型：期刊论文

【摘要】：目的研究雌激素受体(ERα)基因单核苷酸多态性(SNPs,rs2234693、rs9340799)在宁夏回族人群中的分布及其与血脂的关联性。方法以整群抽样的方法选取宁夏银川市社区的回族人群533例,利用基质辅助激光解吸附电离飞行时间质谱分析技术(MassARRAY system)对样本进行基因分型,观察533例回族人群的基因型,同时检测血脂并探讨两者的关系。结果 1rs2234693中各基因型在宁夏回族人群中与其在中国汉族、云南傣族和美国、欧洲、日本的人群中的分布频率无统计学差异(P0.05);rs9340799中各基因型在宁夏回族人群中出现的频率与在欧洲人群中的频率存在着统计学差异(P0.05),与中国汉族、云南傣族及日本人群均无统计学差异(P0.05)。2血脂正常组和血脂异常组一般情况比较显示两组间体质量指数存在明显差异(P0.01)。3rs9340799中GG基因型的个体发生血脂异常的风险增加(OR=2.97,P0.05)。在校正体质量指数后发生血脂异常的风险并没有明显变化(OR=2.76,P0.05)。4rs2234693-rs9340799构成的单体型中C-G在脂代谢异常组的频率略大于脂代谢正常组,但无统计学差异(P0.05)。结论 ERα基因多态性的分布存在着种族的差异;宁夏回族人群中rs2234693的SNPs与血脂异常的发生可能无相关性,而rs9340799中携带有GG基因型的个体发生血脂异常的风险明显增加。
[Abstract]:Objective to study the estrogen receptor (ER) gene single nucleotide polymorphisms (SNPs, rs2234693, rs9340799) in Ningxia Hui population in its correlation with blood lipid. Methods using cluster sampling method to select the Hui population in Ningxia community of Yinchuan city in 533 cases, using matrix assisted laser desorption ionization time of flight mass spectrometry (MassARRAY system) on samples of genotype, genotype were observed in 533 cases of Hui population, and the levels of blood lipids and explore the relationship between them. Results the 1rs2234693 gene type in Ningxia Hui population in China and Europe and the United States of Yunnan Han, Dai, and there was no significant difference in frequency distribution of Japan in the crowd (P0.05); there exist significant differences in the genotype of rs9340799 in Ningxia Hui population in frequency and in Europe in the crowd (P0.05), and China Han, Dai nationality in Yunnan and Japan There was no significant difference in.2 (P0.05) and normal blood lipid group and dyslipidemia group comparison of the general situation shows that there are significant differences between the two groups in body mass index (P0.01) GG genotype.3rs9340799 in the ontogeny of increased risk of dyslipidemia (OR=2.97, P0.05). After adjustment for body mass index after the risk of dyslipidemia and no significant changes (OR=2.76, P0.05).4rs2234693-rs9340799 haplotype in C-G group in the abnormal lipid metabolism is slightly greater than the frequency of lipid metabolism in normal group, but no significant difference (P0.05). The racial differences distribution conclusion ER alpha gene polymorphism; serum lipid and SNPs rs2234693 in Ningxia Hui population in the abnormality may not correlation and rs9340799 in individuals with genotype GG had significantly increased risk of dyslipidemia.

【作者单位】：宁夏医科大学;宁夏医科大学总医院暨生物芯片北京国家工程研究中心宁夏分中心;
【基金】：国家自然科学基金资助项目(No.81160049)~~
【分类号】：R589.2
【正文快照】： 随着我国经济的发展和生活水平的提高,以及人口老龄化问题的到来使得国家乃至个人对老年健康的关注度明显增加。我国流行病学研究资料表明:血脂异常是冠心病发病的危险因素,其作用强度与西方人群相同。血脂异常是老年人心血管疾病的重要危险因素之一,如何防治中老年人的血脂异

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