男性2型糖尿病患者合并低促性腺激素性性腺功能减退的临床观察

发布时间：2018-01-28 01:50

本文关键词： 糖尿病型男性睾酮性腺功能减退　出处：《中国糖尿病杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的探讨男性T2DM患者性腺功能减退的原因。方法选择男性T2DM患者156例,分为低睾酮(TT)组(n=59)和正常TT组(n=97),测定血压、血糖、血脂、胰岛β细胞功能,以及性激素[包括血清TT、性激素结合球蛋白(SHBG)、孕激素(P)、催乳素(PRL)、黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)、脱氢表雄酮(DHEA)],比较两组性激素、糖脂代谢指标及胰岛素等的差异,并分别按BMI及LH进行分组,比较各组间TT水平。结果与正常TT组比较,低TT组BMI、FIns、2 hIns及胰岛素抵抗指数(HOMA-IR)升高(￡=3.76,2.03,2.68,2.13,P0.05),低TT组LH、FSH、SHBG、E2降低(t=-2.94,-2.16,-3.08,-3.50,P0.05);与高体重组比较,低体重组TT增加(P0.05);与低LH组相比,高LH组TT增加(P0.05)。相关分析显示,TT与BMI、FIns及HOMA-IR呈负相关(r=-0.33,-0.18,-0.17,P0.05),与LH、FSH、E2呈正相关(r=0.14,0.16,0.28,P0.05)。结论男性T2DM患者往往会合并低促性激素性性腺功能减退症。
[Abstract]:Objective to investigate the causes of gonadal dysfunction in male patients with T2DM. Methods 156 male patients with T2DM were divided into low testosterone (TTT) group (n = 59) and normal TT group (n = 97). Blood pressure, blood glucose, blood lipids, islet 尾 cell function and sex hormones were measured. [These include serum TTT, sex hormone binding globulin (SHBG), progesterone (P), prolactin (PRL), luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2). The difference of sex hormone, glucose and lipid metabolism index and insulin were compared between the two groups, and were grouped according to BMI and LH. Results compared with the normal TT group, the BMIFIns2 hIns and the insulin resistance index (HOMA-IRR) of the low TT group were increased (3. 76). In low TT group, the level of estradiol decreased from 2.94 to 2.16 and 3.08 to 3.50 in low TT group. P0.05; Compared with the high body weight group, the TT of the low weight group increased P 0.05; Compared with low LH group, TT increased in high LH group (P 0.05). Correlation analysis showed that TT was negatively correlated with BMIFIns and HOMA-IR. (-0.17) P0.05A was positively correlated with FSHE _ 2 of LHH _ (1) 0.14 ~ (0.16) ~ (0.28). Conclusion male patients with type 2 DM are often associated with hypogonadal hypogonadism.
【作者单位】：南京中医药大学附属中西医结合医院内分泌代谢病院区;
【分类号】：R587.1;R698
【正文快照】： 研究[1]发现,超重或肥胖男性糖尿病患者易合并性腺功能减退症,不仅睾酮(TT)降低,黄体生成素(LH)和卵泡刺激素(FSH)也下降。此外,糖尿病所致的性腺功能减退是迟发型性腺功能减退,还是低促性腺激素性性腺功能减退,目前结论不明确。本研究观察男性T2DM患者性激素水平,包括血清TT

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