rhGM-CSF在中老年糖尿病患者体表难愈创面的临床观察

发布时间：2018-02-10 12:52

本文关键词： 长期不愈合伤口重组人粒细胞巨噬细胞刺激因子临床治疗效果观察　出处：《山西医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:通过统计40例rh GM-CSF治疗47-67岁血糖升高病人体表长时间不愈合伤口的治疗效果,评估他治疗47-67岁血糖升高病人体表长时间不愈合伤口的非手术疗法的可行性。方法:选择于2013-03至2013-11在山西医科大学第一医院烧伤整形外科住院治疗的47-67岁血糖升高病人体表长时间不愈合伤口40例,随机分为实验组、对照组两组,每组各20例。试验组:rh GM-CSF凝胶+凡士林纱布治疗组;对照组:凡士林纱布组。试验时长为8周。观察两组伤口色泽及肉芽组织和上皮生长情况,统计两组伤口愈合率,记录用药后的不良反应。结果:入组前两组伤口各方面情况比较差异无统计学意义(P0.05);开始治疗后,两组伤口均有好转趋势,治疗8周后,两组伤口色泽及肉芽组织和上皮生长情况和愈合率比较,差异有统计学意义(P0.05)。结论:rh GM-CSF治疗47-67岁血糖升高病人体表长时间不愈合伤口有良好作用,能促进创面愈合,且没有明显不良反应,可以用来治疗47-67岁血糖升高病人体表长时间不愈合伤口的非手术疗法,既安全又有效,具有临床可行性。
[Abstract]:Objective: to analyze the therapeutic effect of 40 patients with hyperglycemia of 47-67 years old by using Rh GM-CSF to treat non-union wounds in body surface for a long time. To evaluate the feasibility of his non-operative therapy for patients aged 47-67 with hyperglycemia. Methods: 47-67-year-old hyperglycemia was selected from 2013-03 to 2013-11 for in-patient treatment in burn plastic surgery, first Hospital of Shanxi Medical University. There were 40 patients with high body surface who did not heal the wound for a long time. The rats were randomly divided into two groups: experimental group, control group, 20 cases in each group. The control group was treated with Vaseline gauze and the control group was treated with Vaseline gauze. The length of the experiment was 8 weeks. The wound color, granulation tissue and epithelium growth were observed in the two groups. Results: there was no significant difference between the two groups in the wound healing rate and the adverse reactions after medication. Results: there was no significant difference between the two groups in all aspects of the wound, and there was a trend of improvement in the two groups after the beginning of treatment, and after 8 weeks of treatment, there was no significant difference between the two groups in the wound healing rate. There were significant differences in the color and color of wound, the growth of granulation tissue and epithelium and the healing rate between the two groups (P0.050.Conclusion the treatment of body surface non-union wound of 47-67 years old patients with hyperglycemia by w / rh GM-CSF has a good effect and can promote wound healing. It is safe, effective and clinically feasible to treat the patients with hyperglycemia of 47 to 67 years old, which can be used as a non-operative therapy for long time nonunion of wounds in the body surface of patients with hyperglycemia.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.2

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