维吾尔族T2DM患者血清空腹C-肽水平与糖尿病家族史的关系

发布时间：2018-02-15 08:58

本文关键词： 型糖尿病糖尿病家族史 β细胞功能 C-肽维吾尔族　出处：《中国现代医学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨维吾尔族2型糖尿病(T2DM)患者血清空腹C-肽水平与糖尿病(DM)家族史、临床特征的关系,进一步了解DM家族史对T2DM患者残余β细胞功能的影响。方法选取新疆医科大学第一附属医院确诊为T2DM的维吾尔族患者391例,根据有无DM家族史和DM病程进行分组,并比较各组一般资料、血清空腹C-肽水平及血糖、血脂等相关指标。结果 391例患者中有DM家族史123例(31.46%),无DM家族史268例(68.54%);两组在DM病程、体重指数(BMI)、糖化血红蛋白(HbA1c)、空腹血糖、血压、血脂及并发症等方面比较,差异无统计学意义(P0.05),有DM家族史的患者发病年龄较小,收缩压水平低,血清空腹C-肽浓度低;在调整DM病程、BMI、HbA1c、空腹血糖、收缩压、舒张压、总胆固醇、三酰甘油、低密度脂蛋白及高密度脂蛋白等指标后,血清空腹C-肽水平与DM家族史呈负相关(P0.05)。结论在维吾尔族T2DM患者中,DM家族史与血清空腹C-肽水平的逐步下降相关。
[Abstract]:Objective to investigate the relationship between fasting serum C-peptide level and family history and clinical features of patients with type 2 diabetes mellitus (T2DM) in Uygur nationality. Methods 391 Uygur patients with T2DM who were diagnosed as T2DM in the first affiliated Hospital of Xinjiang Medical University were divided into two groups according to the family history of DM and the course of DM. Results among 391 patients, 123 patients had DM family history, while 268 patients had no DM family history. There was no significant difference in body mass index (BMI), glycosylated hemoglobin (HbA1cN), fasting blood glucose, blood pressure, blood lipids and complications. The patients with family history of DM had lower onset age, lower systolic blood pressure and lower serum fasting C-peptide concentration. After adjusting the course of DM, fasting blood glucose, systolic blood pressure, diastolic blood pressure, total cholesterol, triacylglycerol, low density lipoprotein and high density lipoprotein, There was a negative correlation between serum C-peptide level and family history of DM (P0.050.Conclusion in Uygur patients with T2DM, the family history of DM was correlated with the gradual decrease of serum C-peptide level.
【作者单位】：新疆医科大学公共卫生学院劳动卫生与环境卫生教研室;新疆维吾尔自治区人民医院内分泌科;
【基金】：国家自然科学基金(No:81360127)
【分类号】：R587.1

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