西南地区人群尿脂联素水平与2型糖尿病合并冠心病的相关性

发布时间：2018-02-25 17:08

本文关键词： 脂联素型糖尿病冠心病　出处：《中国老年学杂志》2017年15期 　论文类型：期刊论文

【摘要】：目的探讨西南地区人群尿脂联素水平与2型糖尿病(T2DM)合并冠心病(CHD)的相关性。方法采用酶联免疫吸附试验(ELISA)测定23例T2DM患者(T2DM组)和23例T2DM合并CHD患者(DC组)及38例健康对照(NC组)的血、尿脂联素水平,探讨各组脂联素与体重指数(BMI)、腰臀比(WHR)、血脂、血糖、颈动脉中层厚度(IMT)、尿白蛋白/肌酐(ACR)等的关系。结果 DC组尿脂联素水平较T2DM组及NC组均明显升高(分别为20.91±4.59 vs 17.75±1.90μg/ml,20.91±4.59 vs 13.61±5.74μg/ml,P0.01),T2DM组较NC组明显升高;DC组血清脂联素水平也明显升高(分别为5.73±1.78 vs 8.43±3.55μg/ml,5.73±1.78 vs 14.46±4.18μg/ml,P0.01)。线性相关分析表明T2DM组尿脂联素水平与血清脂联素相关,而DC组则还与糖化血红蛋白(Hb A1c)、总胆固醇(TC)、ACR相关,进一步行多元逐步回归分析表明,DC组影响尿脂联素水平的独立危险因素为ACR、Hb A1c及TC是(Y尿脂联素=0.004X ACR+2.83XHBA1C+4.055XTC-30.224)。结论尿脂联素水平改变与T2DM大血管病变有关,其参与了T2DM合并CHD的发生发展。
[Abstract]:Objective to investigate the correlation between urinary adiponectin levels and type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD) in southwest China. Methods Enzyme-linked immunosorbent assay (Elisa) was used to determine 23 T2DM patients with T2DM and 23 T2DM patients with CHD. Blood samples from 38 healthy controls (NC group), Urine adiponectin levels, adiponectin and body mass index (BMI), waist to hip ratio (WHR), blood lipid, blood glucose, Results urinary adiponectin level in DC group was significantly higher than that in T2DM group and NC group (20.91 卤4.59 vs 17.75 卤1.90 渭 g / ml 卤4.59 vs 13.61 卤5.74 渭 g / ml P0.01T2DM vs NC group, respectively). The levels of urinary adiponectin in T2DM group were significantly increased (5.73 卤1.78 vs 8.43 卤3.55 渭 g / ml, 5.73 卤1.78 vs 14.46 卤4.18 渭 g / ml / ml, respectively). Linear correlation analysis showed that the level of urinary adiponectin was correlated with serum adiponectin in T2DM group. The DC group was also associated with HbA1cN and TCU ACR. Multivariate stepwise regression analysis showed that the independent risk factors of urinary adiponectin level in DC group were ACR-HbA1c and TC were 0.004X ACR 2.83XHBA1C 4.055XTC-30.2240.Conclusion the change of urinary adiponectin level is related to the macroangiopathy of T2DM. It participated in the occurrence and development of T2DM combined with CHD.
【作者单位】：重庆医药高等专科学校临床医学院;重庆医科大学附属永川医院内分泌科;
【基金】：重庆市卫生局课题(2012-2-155) 永川区科委课题(YCSTC,2012BE5005) 重庆医科大学附属永川医院院级课题(YJYJ20120001)
【分类号】：R541.4;R587.1

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