滋水清肝饮加减联合前列地尔对肝肾阴虚型糖尿病周围神经病变患者外周血GSH、NF-κB及肝肾功能的影响

发布时间：2018-03-01 13:33

本文关键词： 非糖尿病周围神经病变滋水清肝饮肝肾阴虚核转录因子肝肾功能　出处：《中华中医药学刊》2017年03期 　论文类型：期刊论文

【摘要】：目的:滋水清肝饮加减联合前列地尔对肝肾阴虚型糖尿病周围神经病变(DPN)患者外周血还原性谷胱甘肽(GSH)、单个核细胞(NF-κB)及肝肾功能的影响。方法:将82例肝肾阴虚型DPN患者采用随机数字表法分为对照组和观察组,各41例。对照组给予前列地尔治疗,观察组在对照组基础上给予滋水清肝饮治疗,均以30 d为1个疗程,治疗2个疗程。评估临床疗效,测定正中神经、右腓肠神经的运动传到速度(MCV)、感觉传导速度(SCV),检测糖化血红蛋白(HbAlc)、还原性谷胱甘肽(GSH)、超氧化物歧化酶(SOD)、丙二醛(MDA)、单个核细胞(NF-κB)活性及肝肾功能指标。结果:观察组治疗后正中神经及右腓肠神经的MCV、SCV明显高于对照组(P0.05);观察组治疗后GSH、SOD高于对照组,MDA低于对照组(P0.05);观察组治疗后NF-κB、HbAlc低于对照组(P0.05);两组治疗前后肝肾功能指标无差异(P0.05)。结论:滋水清肝饮加减联合前列地尔治疗肝肾阴虚型DPN,可通过降低机体应激反应、抑制NF-κB活化发挥治疗作用,且对肝肾功能无影响。
[Abstract]:Objective: to study the effects of addition and subtraction of Zishui Qinggan decoction combined with alprostadil on reduced glutathione glutathione glutathione (GSH), NF- 魏 B in mononuclear cells and liver and kidney function in patients with diabetic peripheral neuropathy of liver-kidney yin deficiency type. Methods: 82 cases of liver and kidney yin deficiency were studied. Patients with DPN were randomly divided into two groups: control group and observation group. 41 cases each. The control group was treated with alprostadil, while the observation group was treated with Zishuiqinggan Yin on the basis of the control group. All patients were treated for 30 days as a course of treatment for 2 courses of treatment. The clinical effect was evaluated and the median nerve was measured. The movement of right sural nerve to MCV, sensory conduction velocity to SCV, detection of HbAlcP, GSH, SOD, MDAA, NF- 魏 B activity of mononuclear cells and liver and kidney function were observed. After treatment, the median nerve and the right sural nerve in the observation group were significantly higher than those in the control group (P 0.05A), the GSH SOD in the observation group was higher than that in the control group and the MDA in the control group was lower than that in the control group (P 0.05), the NF- 魏 B HbAlc in the observation group was lower than that in the control group (P 0.05), and there was no difference in the indexes of liver and kidney function between the two groups before and after treatment. Conclusion: the combination of Zishui Qinggan Yin and alprostadil in the treatment of liver and kidney yin deficiency type DPN can reduce the stress response of the body. Inhibition of NF- 魏 B activation plays a therapeutic role and has no effect on liver and kidney function.
【作者单位】：浙江省人民医院内分泌科;浙江省人民医院中医科;
【基金】：浙江省医药卫生重点计划项目(2012ZDA003)
【分类号】：R587.2

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