血清前列腺特异性抗原在多囊卵巢综合征患者中的水平变化及其诊断价值

发布时间：2018-03-08 16:00

本文选题：多囊卵巢综合征　切入点：前列腺特异性抗原　出处：《山东医药》2017年13期 　论文类型：期刊论文

【摘要】：目的探讨血清前列腺特异性抗原(PSA)在多囊卵巢综合征(PCOS)患者中的水平变化及其诊断价值。方法选择50例PCOS患者(PCOS组)及60例正常女性(对照组),测量受试者身高、体质量、腰围,并计算体质量指数(BMI)。采用化学发光法检测血清PSA、游离PAS(fPSA)、睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)、胰岛素,葡萄糖氧化酶法检测空腹血糖。用ROC曲线行诊断试验评价,并与血清T和LH/FSH的诊断价值进行比较。结果与对照组比较,PCOS组BMI、空腹血糖、空腹胰岛素高(P0.05或0.01)。与对照组比较,PCOS组血清LH、LH/FSH、T、fPSA、PSA高(P0.05或0.01)。血清PSA水平与腰围、空腹胰岛素、LH、T、LH/FSH存在正相关(r分别为0.22、0.32、0.19、0.41、0.26,P均0.05),血清fPSA水平与腰围、空腹胰岛素、LH、LH/FSH存在正相关(r分别为0.27、0.25、0.28、0.32,P均0.05)。血清PSA的曲线下面积(AUC)为0.829(95%CI 0.752~0.907,P0.01),血清fPSA的AUC为0.777(95%CI 0.689~0.864,P0.01)。血清PSA诊断PCOS价值高于LH/FSH(AUC 0.721,95%CI 0.624~0.819)(P=0.022),与T相似(AUC 0.748,95%CI 0.652~0.844,P=0.074)。血清fPSA诊断PCOS价值与LH/FSH(P=0.419)及T(P=0.738)相似。中国PCOS人群较好的血清PSA诊断界值为12.95 pg/m L(灵敏度76%,特异度77%),而血清fPSA的诊断界值为2.43 pg/m L(灵敏度77%,特异度65%),诊断价值与T和LH/FSH相似。结论 PCOS患者血清PSA水平升高。PSA检测对PCOS具有较好的诊断价值。
[Abstract]:Objective to investigate the changes of serum prostate specific antigen (PSA) in patients with polycystic ovary syndrome (PCOS) and its diagnostic value. Methods 50 patients with PCOS and 60 normal women (control group) were selected to measure their height and body weight. Waist circumference and body mass index (BMI) were calculated. Serum PSAs, free PASF PSAs, testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH), insulin and glucose oxidase were measured by chemiluminescence assay. The diagnostic value of serum T and LH/FSH was compared with that of control group. Results compared with the control group, the serum PSA level and waist circumference were significantly higher than those in the control group (P 0.05 or 0.01). The serum PSA level and waist circumference were significantly higher than those in the control group (P 0.05, P < 0.05), and compared with those in the control group (P < 0.01), and compared with the control group, the serum PSA level and the waist circumference were significantly higher than those in the control group (P 0.05, P < 0.01). The positive correlation r of LH / FSH was 0.22 ~ 0.32 ~ 0.19 ~ 0.41 ~ 0.26 ~ (-1) P, respectively. The serum fPSA level and waist circumference were all 0. 05 ~ 0. 05%. The positive correlation r of LH / FSH was 0.27 / 0.25 / 0.280.32 / 0.5.The area under the curve of serum PSA was 0.82995 CI 0.7522 / 0.907 / P0.01a, and the AUC of serum fPSA was 0.7779 / 95 CI 0.6890.864P0.01. the value of serum PSA in diagnosis of PCOS was higher than that of LH/FSH(AUC 0.72195CI (0.8280.19) P0. 02222, similar to that of UC A0. 748c0.652c0 / 0.844P0.0740.The value of serum fPSA PCOS diagnosis was higher than that of LH/FSH(AUC 0.729595 CI 0. 819 P0. 02222, and similar to that of UC0. 74895 CI 0. 652C0. 8444P0. 07474) and the value of serum fPSA PCOS was higher than that of LH/FSH(AUC 0.729595 CI 0. 68995 CI 0. 819 9 P0. 02222, similar to that of UC0. 74895 CI 0. 652C0. 844P0. 074. The diagnostic threshold of serum PSA in Chinese PCOS population was 12.95 pg/m / L (sensitivity 76, specificity 77g / L), while the diagnostic threshold of serum fPSA was 2.43 pg/m L (sensitivity 77, specificity 65g / L). The diagnostic value was similar to that of T and LH/FSH. Conclusion the diagnostic value of serum fPSA is similar to that of T and LH/FSH. The detection of elevated serum PSA. PSA has good diagnostic value for PCOS.
【作者单位】：成都市第二人民医院;
【基金】：2016年四川省卫生和计划生育委员会科研课题(普及应用项目)(16PJ030)
【分类号】：R711.75

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