2型糖尿病和结直肠癌的相关性的Meta分析

发布时间：2018-03-10 22:46

  本文选题：结直肠癌　切入点：2型糖尿病　出处：《新疆医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：本研究拟对结直肠癌和2型糖尿病相关性的文献进行Meta分析。方法：计算机检索美国国立医学图书馆旗下的PubMed数据库、美国医学索引旗下的Medline数据库、荷兰医学文摘旗下的EMbase数据库、万方数据知识服务平台旗下的数字化期刊全文数据库、中国知网旗下的相关期刊论文、中国生物医学数据库、维普资讯旗下的中文科技期刊数据库等1999年到2013年发表的关于结直肠癌和2型糖尿病的相关性的研究和文献。并辅以手工检索中、英文已发表的资料和会议论文并追索纳入文献的参考文献,使用RevMan5.3软件进行Meta分析。结果：共纳入8篇文献,纳入的文献发表年限为1999年到2013年,总病例数为416602例。8篇文献中病例数从14109例到118072例不等。其中各有4个研究分别单独研究女性及男性发病情况,有两篇文献对男性和女性的发病均有研究。这8个研究均研究的是2型糖尿病患者,通过病史询问及发病时年龄判断为2型糖尿病。Meta分析显示,2型糖尿病患者罹患结直肠癌的风险是正常对照组的1.39倍[95%CI(1.27,1.53),P0.00001]。结论：研究结果表明了结直肠癌的发病与2型糖尿病具有相关性,因此建议对2型糖尿病人群的定期体检及随访中进行消化道肿瘤的筛查。
[Abstract]:Objective: to analyze the relationship between colorectal cancer and type 2 diabetes by Meta. Methods: the PubMed database of the National Library of Medicine and the Medline database of the American Medical Index were searched by computer. The EMbase database of Dutch Medical Abstracts, the full text Database of Digital Journals under Wanfang data knowledge Service platform, the full text Database of Chinese Journals under China knowledge Network, the Chinese Biomedical Database, From 1999 to 2013, the database of Chinese science and technology journals of WIP Information has published research and literature on the correlation between colorectal cancer and type 2 diabetes. The published materials and conference papers in English were used for Meta analysis with the help of RevMan5.3 software. Results: eight articles were included, and the published years were from 1999 to 2013. The total number of cases ranged from 14109 to 118072 in 416602 articles. There are two articles that study both men and women who develop type 2 diabetes. Meta-analysis showed that the risk of colorectal cancer in patients with type 2 diabetes mellitus was 1.39 times higher than that in the normal control group. Conclusion: the results showed that the risk of colorectal cancer in patients with type 2 diabetes mellitus was 1.39 times higher than that in the normal control group. Conclusion: the results of the study indicate that the incidence of colorectal cancer is associated with the incidence of colorectal cancer. Type 2 diabetes is associated, It is suggested that type 2 diabetes should be screened for digestive tract tumors during regular physical examination and follow-up.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1;R735.34
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本文编号：1595407