169例中草药致药物性肝损伤的文献分析

发布时间：2018-03-17 11:36

本文选题：中草药　切入点：肝损伤　出处：《时珍国医国药》2017年04期 　论文类型：期刊论文

【摘要】：目的分析中草药引起药物性肝损伤的药物因素、患者因素、临床表现,总结导致肝损伤的中草药品种,为药物性肝损伤的预防诊断治疗提供参考。方法检索万方数据库(Wanfangdata)、相关期刊论文(CNKI)、维普中文科技期刊全文数据库(VIP)和中国生物医学文献数据库(CBM)中1964年1月至2016年7月有关药物性肝损伤的病例报告,并对文献资料进行整理、汇总、分析。结果药物性肝损伤病例报道呈逐年上升趋势。共确定中草药肝损伤文献132篇,病例数为169例,男性79例,女性90例,并明确有14种中草药具有潜在的肝毒性,以何首乌、土三七引起的肝损伤多见。高发年龄段41~50岁(26.6%)及51~60岁(23.1%)。中草药导致药物性肝损伤的发生时间在服药后7天内、2周至3个月内最常见。临床表现以厌食厌油、乏力,腹胀腹痛,恶心呕吐、尿黄、皮肤巩膜黄染多见。169例患者中好转16例,无好转7例,死亡11例,肝移植2例,痊愈133例。结论 14种中草药可引起药物性肝损伤,临床用药过程中应注意。
[Abstract]:Objective to analyze the drug factors, patient factors and clinical manifestations of drug-induced liver injury caused by Chinese herbal medicine, and to summarize the varieties of Chinese herbal medicine that lead to liver injury. Methods to search Wanfangdataan database, CNKI database, VIPM database and CBM database of Chinese scientific and technological journals and Chinese biomedical literature database on 1964. Case reports of drug-induced liver injury from June to July 2016, Results the reports of drug-induced liver injury cases showed an increasing trend year by year. A total of 132 articles of Chinese herbal medicine liver injury were confirmed, 169 cases were reported, 79 cases were males and 90 cases were females. And it is clear that there are 14 Chinese herbal medicines with potential hepatotoxicity to Polygonum multiflorum, Liver injury caused by Panax notoginseng is more common. The high incidence age group is 41 ~ 50 years old or 26.60.The incidence time of drug-induced liver injury caused by Chinese herbal medicine is the most common within 2 weeks to 3 months after taking medicine. The clinical manifestations are anorexia, fatigue, abdominal distention and abdominal pain. Nausea and vomiting, urine yellow, skin and scleral yellow stain were mostly improved in 16 cases, no improvement in 7 cases, death in 11 cases, liver transplantation in 2 cases, recovery in 133 cases. Conclusion 14 kinds of Chinese herbal medicine can cause drug-induced liver injury, and should be paid attention to in the course of clinical treatment.
【作者单位】：天津医科大学;天津市第一中心医院药学部;
【分类号】：R595.3

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