肠道菌群与骨质疏松关系的研究进展

发布时间：2018-03-17 14:50

本文选题：肠道菌群　切入点：骨质疏松　出处：《南方医科大学学报》2017年02期 　论文类型：期刊论文

【摘要】：随着我国老年化的不断向前发展,骨质疏松及其带来的严重并发症——骨折的发病率也不断提高,已成为威胁老年人生活质量的常见健康问题之一。肠道菌群定植在人体肠道当中,与宿主之间构成一定的互利共生关系,对宿主的代谢及免疫调节发挥着重要的作用。近年来越来越多研究发现肠道菌群不仅对消化系统产生影响,对免疫系统相关疾病也具有重要影响,同时与骨质疏松的发病、发展关系密切。本研究从肠道菌群与免疫系统、骨质疏松与免疫系统、肠道菌群与骨质疏松、骨质疏松的肠道菌群防治等方面进行综述,总结近年来的研究进展及热点,搭建肠道菌群与骨质疏松等相关多学科之间的桥梁,为骨质疏松的菌群治疗、靶点研究奠定基础。
[Abstract]:With the development of aging in China, the incidence of osteoporosis and its serious complication, fracture, is also increasing. It has become one of the common health problems threatening the quality of life of the elderly. The intestinal flora is colonized in the human gut and forms a mutually beneficial symbiotic relationship with the host. It plays an important role in host metabolism and immune regulation. In recent years, more and more studies have found that the intestinal flora not only has an effect on the digestive system, but also on the immune system related diseases, at the same time, it is associated with the pathogenesis of osteoporosis. In this study, the microflora and immune system of intestinal tract, osteoporosis and immune system, intestinal flora and osteoporosis, prevention and treatment of intestinal flora of osteoporosis were reviewed, and the research progress and hot spots in recent years were summarized. To build the bridge between intestinal microflora and osteoporosis and so on, to lay a foundation for the treatment and target research of osteoporosis.
【作者单位】：广州中医药大学第二附属医院;广州中医药大学第三附属医院;广州中医药大学第一附属医院;
【基金】：国家自然科学基金(81473699)~~
【分类号】：R580

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