碘与酪氨酸交互作用对小鼠甲状腺形态变化的动态对比研究

发布时间：2018-03-20 08:30

本文选题：高碘　切入点：甲状腺形态学　出处：《中国地方病防治杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的动态研究高碘与高酪氨酸对小鼠甲状腺形态结构变化的影响。方法将150只昆明种小鼠随机分为对照组(NI)、高碘组(HI)、高酪氨酸组(Htyr)、高碘高酪氨酸组(HI+Htyr)和高碘模型组(HIM)5组。在实验10周、20周和30周时,测定小鼠甲状腺绝对质量与相对质量,观察小鼠甲状腺组织形态变化。结果 20周时,HI组小鼠甲状腺相对质量显著高于NI组;30周时,HI+Htyr组小鼠甲状腺相对质量显著高于NI组。光镜结果显示,HI组呈现典型的胶质性甲状腺肿;同时HI+Htyr组也呈现出胶质性甲状腺肿的改变,但滤泡腔胶质减少。结论补充适量的酪氨酸可以减轻高碘对甲状腺组织的损伤作用,延缓昆明种小鼠甲肿的发生,但不能阻止高碘甲状腺肿的形成,说明在水碘为300μg/L的情况下,碘对甲状腺肿的作用是主要的,酪氨酸的作用是次要的。
[Abstract]:Objective to study the effect of high iodine and high tyrosine on the changes of thyroid morphology in mice. Methods 150 Kunming mice were randomly divided into control group, high iodine group, high tyrosine group and high iodine group, respectively. Group A was treated with HIMM 5. At the 10th week, 20 weeks and 30 weeks after the experiment, The absolute and relative mass of thyroid gland in mice was determined. Results the relative mass of thyroid in HI group was significantly higher than that in NI group at 30 weeks. The results showed that the thyroid relative mass in HI Htyr group was significantly higher than that in NI group at 30 weeks. Type A glial goiter; In HI Htyr group, glial goiter was also observed, but the glia of follicular cavity was decreased. Conclusion supplementation of tyrosine can attenuate the injury of thyroid tissue induced by iodine, and delay the occurrence of goiter in Kunming mice. But it can not prevent the formation of iodine goiter, indicating that the effect of iodine on goiter is primary and tyrosine is secondary when iodine is 300 渭 g / L in water.
【作者单位】：齐齐哈尔医学院公共卫生学院;甘肃省医学科学研究院;哈尔滨医科大学中国疾病预防控制中心地方病控制中心碘缺乏病防治研究所;
【基金】：国家自然科学基金(No.81172606) 齐齐哈尔市科学技术计划项目(SFZD-2014018)
【分类号】：R581

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