乌拉地尔注射液治疗老年高血压合并糖尿病急性心力衰竭发作患者的有效性与安全性

发布时间：2018-03-24 02:16

本文选题：乌拉地尔　切入点：硝酸甘油　出处：《中国新药杂志》2017年15期

【摘要】：目的:对比分析乌拉地尔与硝酸甘油注射液治疗老年高血压合并糖尿病患者急性心力衰竭发作的临床有效性与安全性。方法:回顾性分析2014年7月—2016年10月我院接治的94例高血压合并糖尿病急性心力衰竭发作患者的临床记录资料,对照组给予硝酸甘油注射液,治疗组给予乌拉地尔注射液,两组治疗时间均为1周。比较两组治疗前、治疗1周后患者的舒张压(DBP)、收缩压(SBP)、心率(HR)等观察指标和N末端B型利钠肽原(NT-proBNP)、左心室射血分数(LVEF)等心功能指标的变化,另外比较两组治疗前、治疗1周后患者的肌酐、胆固醇、低密度脂蛋白(LDL)以及空腹血糖等生化指标。结果:治疗后,治疗组患者的肌酐和胆固醇水平均显著低于对照组(P0.05);治疗组患者的空腹血糖水平显著低于对照组(P0.05)。治疗后,治疗组的SBP,NT-proBNP水平和不良反应发生率均低于对照组,LVEF显著高于对照组(P0.05)。结论:乌拉地尔治疗老年高血压合并糖尿病患者急性心力衰竭发作的临床效果显著,值得推广应用。
[Abstract]:Objective: to compare the efficacy and safety of urapidil and nitroglycerin injection in the treatment of acute heart failure in elderly patients with hypertension and diabetes mellitus. Methods: from July 2014 to October 2016, the clinical efficacy and safety of urapidil and nitroglycerin injection were analyzed retrospectively. Clinical records of 94 patients with hypertension complicated with diabetes acute heart failure, The control group was given nitroglycerin injection, the treatment group was given urapidil injection, the two groups were treated for 1 week. The changes of DBP, SBP, HRR and NT-proBNPN, left ventricular ejection fraction (LVEFF) were compared between the two groups before and after 1 week of treatment, and creatinine was compared between the two groups before and after 1 week of treatment. Results: after treatment, the levels of creatinine and cholesterol in the treatment group were significantly lower than those in the control group (P 0.05), and the fasting blood glucose level in the treatment group was significantly lower than that in the control group (P 0.05). The level of SBPnT-proBNP and the incidence of adverse reactions in the treatment group were significantly lower than those in the control group (P 0.05). Conclusion: the clinical effect of urapidil in the treatment of acute heart failure in elderly patients with hypertension and diabetes is significant, and it is worth popularizing.
【作者单位】：郑州市第七人民医院药剂科;
【分类号】：R541.6;R544.1;R587.1

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