男男同性恋HIV耐药的Meta分析

发布时间：2018-03-24 02:34

  本文选题：艾滋病病毒　切入点：原发性耐药　出处：《中南大学学报(医学版)》2017年06期

【摘要】：目的:了解男男同性恋(men who have sex with men,MSM)艾滋病原发性耐药及耐药基因突变位点现状。方法:检索CNKI,VIP,CBM,万方数据库,Pub Med,Web of Knowledge,Springer及Medline数据库,提取HIV耐药以及耐药基因突变位点数据,对效应量进行合并,并对样本量、地区、人种、质量评价得分及采样时间进行亚组分析。结果:共纳入43篇文献,MSM未治疗HIV感染者总耐药率、蛋白酶抑制剂(proteinase inhibitors,PI)耐药率、核苷类反转录酶抑制剂(nucleoside reverse transcriptase inhibitors,NRTI)耐药率、非核苷类反转录酶抑制剂(non nucleoside reverse transcriptase inhibitors,NNRTI)耐药率分别为10.21%(95%CI:8.65%~12.03%),2.98%(95%CI:2.25%~3.93%),4.05%(95%CI:3.14%~5.21%),4.42%(95%CI:3.31%~5.88%)。PI主要突变位点、PI次要突变位点、NRTI突变位点、NNRTI突变位点的突变位点频数≥3的突变率分别为0.55%(95%CI:0.38%~0.80%),1.31%(95%CI:0.98%~1.75%),0.85%(95%CI:0.51%~1.40%),1.19%(95%CI:0.70%~2.01%);频数3的突变率分别为0.79%(95%CI:0.55%~1.13%),1.73%(95%CI:1.21%~2.46%),0.86%(95%CI:0.61%~1.21%),2.24%(95%CI:1.77%~2.83%)。样本量、地区及人种均是异质性的来源,耐药率和基因突变位点突变率在不同的亚组中分布不同。结论:美洲、欧洲地区MSM原发性耐药率较高,亚洲地区较以往也有所升高;同时PI次要突变位点突变率亦较高,应引起重视。
[Abstract]:Objective: to investigate the status of who have sex with with mutation in HIV / AIDS. Methods: the data of HIV resistance and drug resistance gene mutation sites were extracted from the database of who have sex with with. Methods: the data of HIV drug resistance and drug resistance gene mutation were retrieved from the database of who have sex with. Methods: the data of HIV drug resistance and drug resistance gene mutation were retrieved from the database of Pub Medweb of Knowledgestringer Springer and Medline. The subgroup analysis of sample size, region, race, quality evaluation score and sampling time was carried out. Results: total drug resistance rate and protease inhibitor inhibitor PI- resistance rate were analyzed in 43 articles. Nucleoside reverse transcriptase inhibitors NRTI, a nucleoside reverse transcriptase inhibitor, showed high drug resistance. Non nucleoside reverse transcriptase inhibitor NNRTI) resistance rates were 10.2195 / 95CI8.65CI2.98 / 2.98C 2.933.95 / 4.053.05 / 95 / 95 CI: 4.422i. The percentage of NRTI mutation frequency 鈮，

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