阻塞性睡眠呼吸暂停低通气综合征并2型糖尿病患者血清肿瘤坏死因子-α和血浆内皮素的变化及意义

发布时间：2018-03-24 22:26

本文选题：睡眠呼吸暂停低通气综合征　切入点：阻塞性　出处：《临床耳鼻咽喉头颈外科杂志》2016年03期

【摘要】：目的:探讨肿瘤坏死因子-α(TNF-α)和血浆内皮素(ET)在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并2型糖尿病(T2DM)病理生理过程中的意义。方法:观察80例OSAHS患者(OSAHS组)、65例OSAHS合并T2DM患者(OSAHS+T2DM组)、20例T2DM患者(T2DM组)、32名健康者(对照组)。采用双抗体夹心酶联免疫吸附法检测上述4组研究对象的血清TNF-α和ET水平,比较OSAHS组与OSAHS+T2DM组患者经持续正压通气(CPAP)或手术治疗3个月后的TNF-α、ET含量的变化。结果:OSAHS+T2DM组血清TNF-α水平高于OSAHS组、T2DM组和对照组(均P0.05);OSAHS组和T2DM组血清TNF-α水平高于对照组;OSAHS组和T2DM组之间血清TNF-α水平无差异;4组之间ET水平无显著性差异。在OSAHS组、OSAHS+T2DM两组中,血清TNF-α在治疗前后分别进行比较,差异均有统计学意义(P0.05),其中OSAHS+T2DM组治疗前后比较有显著性差异(P0.01),而OSAHS组、OSAHS+T2DM两组ET在治疗前后比较均无差异(P0.05)。结论:TNF-α可能参与了OSAHS并T2DM的发生发展过程,而ET可能对OSAHS并T2DM的发生发展过程影响不大。
[Abstract]:Objective: to investigate the significance of tumor necrosis factor- 伪 (TNF- 伪) and plasma endothelin (et) in the pathophysiological process of obstructive sleep apnea hypopnea syndrome (OSAHS) combined with type 2 diabetes mellitus (T2DM). The serum levels of TNF- 伪 and et were measured by double antibody sandwich enzyme-linked immunosorbent assay (Elisa) in 32 healthy controls (control group) in 20 T2DM patients with OSAHS T2DM. The changes of TNF- 伪 et levels in OSAHS group and OSAHS T2DM group after continuous positive pressure ventilation (CPAP) or surgical treatment for 3 months were compared. Results the serum TNF- 伪 level in OSAHS group was higher than that in OSAHS group T2DM group and control group (both P0.05OSAHS group and T2DM group were higher than that in control group). There was no significant difference in serum TNF- 伪 levels between T2DM and OSAHS groups, and there was no significant difference in et level between four groups. In OSAHS group, there was no significant difference in serum TNF- 伪 level between OSAHS group and T2DM group. Serum TNF- 伪 was compared before and after treatment. There was significant difference between the two groups before and after treatment in OSAHS T2DM group, but there was no significant difference in et between the two groups before and after treatment in OSAHS group. Conclusion: TNF- 伪 may be involved in the occurrence and development of OSAHS and T2DM. Et may have little effect on the occurrence and development of OSAHS and T2DM.
【作者单位】：甘肃省人民医院甘肃省睡眠医学中心;甘肃省武山县人民医院内分泌科;
【基金】：天水市科技局项目[No:天财建(2014)389号]
【分类号】：R766;R587.1

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