依折麦布对糖尿病前期不稳定性心绞痛患者胰岛素释放的影响

发布时间：2018-04-01 14:29

本文选题：依折麦布　切入点：不稳定性心绞痛　出处：《中国动脉硬化杂志》2017年03期

【摘要】：目的观察依折麦布对糖尿病前期不稳定性心绞痛患者胰岛素释放的影响。方法选取糖尿病前期不稳定性心绞痛患者222例,随机分为对照组和依折麦布组,对照组给予阿托伐他汀治疗;依折麦布组给予阿托伐他汀联合依折麦布治疗,分别治疗7天、1月、3月,比较两组葡萄糖耐量试验(OGTT)和胰岛素释放试验(IRT)结果。结果与对照组比较,依折麦布组7天、1月、3月OGTT 0.5 h、1 h、2 h血糖显著降低(P0.05、0.01),0.5 h、1 h、2 h、3 h血糖曲线下面积显著减少(P0.05、0.01、0.001);IRT 0.5 h、1 h胰岛素明显升高(P0.05、0.01),2 h胰岛素降低(P0.05),0.5 h、1 h、2 h胰岛素曲线下面积增加(P0.01、0.001、0.05)。不同时间点血糖曲线下面积和胰岛素曲线下面积存在负相关(r=-0.387,P0.01);不同时间段血糖减低量与胰岛素增加量存在正相关(r=0.473,P0.001)。与对照组比较,依折麦布组稳态模型胰岛素抵抗指数于1月、3月明显降低(P0.05、0.01);胰岛素作用指数于7天、1月、3月明显升高(P0.05、0.01);稳态模型-β于3月明显升高(P0.05)。结论依折麦布改善糖尿病前期不稳定性心绞痛患者胰岛素分泌,提高胰岛素敏感性,改善糖耐量。
[Abstract]:Objective to observe the effect of ezeimebum on insulin release in patients with prediabetic unstable angina pectoris. Methods 222 patients with prediabetic unstable angina pectoris were randomly divided into two groups: control group and ezeimebum group. The control group was treated with Atto vastatin, while the Ezeimebumin group was treated with Atto vastatin combined with ezeimebumin for 7 days, 1 month and 3 months, respectively. The results of glucose tolerance test (OGTT) and insulin release test (IRTT) were compared between the two groups. After 7 days, 1 month and 3 months of OGTT, the blood glucose decreased significantly under the blood glucose curve of P0.05H0. 01U 0. 05hU and 0. 5hU / 2 h. The area under the blood glucose curve of P0. 05hu 0. 01 and 0. 001h IRT0. 001h increased significantly (P 0. 05, 0. 01 h) and decreased the area under the insulin curve of P0. 05, 0. 5 hU, 1 h, 2 h, and increased significantly the area under the insulin curve of P0. 05, 0. 5, 1? h, 1? h, 1? h??? There was a negative correlation between the area under the blood glucose curve and the area under the insulin curve at different time points, and there was a positive correlation between the decrease of blood glucose and the increase of insulin at different time points. Compared with the control group, there was a positive correlation between the decrease of blood glucose and the increase of insulin, compared with the control group, there was a negative correlation between the area under the blood glucose curve and the area under the insulin curve. The insulin resistance index of steady state model in ezeimebum group decreased significantly in January and March, the insulin action index increased significantly in 7 days, 1 month and 3 months, and the steady-state model 尾 increased significantly in 3 months. Conclusion Ezeimebum can improve the prediabetes mellitus. Insulin secretion in patients with unstable angina pectoris, Improve insulin sensitivity and glucose tolerance.
【作者单位】：开封市中心医院心内科;
【基金】：开封市科技创新人才计划项目开封市创新型科技团队计划项目(汴科124号)
【分类号】：R541.4;R587.1

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