老年2型糖尿病患者罹患阿司匹林抵抗的临床特征

发布时间：2018-04-01 16:38

本文选题：型糖尿病　切入点：阿司匹林抵抗　出处：《中国老年学杂志》2017年12期

【摘要】：目的探讨老年2型糖尿病(T2DM)患者罹患阿司匹林抵抗(AR)的临床特征。方法选取服用拜阿司匹林100 mg/d持续7 d以上的老年T2DM患者100例,依据血小板聚集率分为AR组和阿司匹林敏感(AS)组,分析两组的临床特征。结果两组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白(Apo)B、脂蛋白(LP)(a)、活化部分凝血酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)、糖化血红蛋白(Hb A1c)水平较高,其中两组Fib和Hb A1c差异有统计学意义(P0.05),其他指标差异无统计学意义(P0.05);甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、Apo A1、Apo E、凝血酶原时间(PT)、D二聚体水平较低,其中两组Apo A1差异有统计学意义(P0.05),其他指标差异无统计学意义(P0.05)。Apo A1每增加1%,AR的发生率就减少0.9%;而Fib和Hb A1c为危险因素,Fib每增加1%,AR的发生率就增加1.944倍;Hb A1c每增加1%,AR的发生率就增加1.239倍。结论在老年T2DM患者中,Apo A1水平降低、Fib和Hb A1c水平升高,合并冠心病和(或)下肢动脉粥样性闭塞症的患者易发生AR。
[Abstract]:Objective to investigate the clinical characteristics of elderly patients with type 2 diabetes mellitus (T2DM) suffering from aspirin resistance to AR.Methods 100 elderly patients with T2DM who took aspirin for more than 7 days were selected. According to platelet aggregation rate, they were divided into AR group and aspirin sensitive ASgroup. Results the clinical characteristics of the two groups were analyzed. Results the levels of total cholesterol TCU, low density lipoprotein cholesterol (LDL-Cn), apolipoprotein (ApoB), lipoprotein (LP), activated partial thrombin time (APTTT), thrombin time (TTT), fibrinogen (Fib), glycosylated hemoglobin (HB A _ 1c) in the two groups were higher than those in the control group. There were significant differences in Fib and HbA1c between the two groups (P 0.05), but there was no significant difference in other indexes (P 0.05), and the levels of triglyceride (TG), high density lipoprotein cholesterol (HDL-C), high density lipoprotein cholesterol (HDL-C), high density lipoprotein cholesterol (HDL-C), high density lipoprotein cholesterol (HDL-C), and prothrombin time (PT) were lower. The difference of Apo A1 between the two groups was statistically significant (P 0.05). There was no significant difference in other indexes. The incidence of AR was decreased by 0.9 for every increase of ApoA1, while the incidence of Fib and HB A1c was increased by 1.944 times for each increase of HbA1c, while the incidence of HbA1c increased by 1.944 times for each increase of HbA1c in Fib and HB A1c. Conclusion in elderly T2DM patients, the levels of Apo A1 decreased and the levels of Fib and HbA1c increased. ARs are likely to occur in patients with coronary heart disease and / or lower extremity atherosclerosis.
【作者单位】：北京老年医院内分泌科;
【基金】：北京老年医院院内课题(2011bjlnyy-自-1)
【分类号】：R587.1

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