不同剂量骨化三醇治疗绝经后骨质疏松疗效对比

发布时间：2018-04-09 15:18

本文选题：骨化三醇　切入点：绝经后骨质疏松　出处：《中国骨质疏松杂志》2017年06期

【摘要】：目的对比不同剂量骨化三醇治疗绝经后骨质疏松的临床疗效。方法将我院门诊治疗的786例绝经后骨质疏松患者随机分为两组,每组393例。一组给予骨化三醇0.25μg(骨化三醇0.25μg治疗组),每日一次;另一组给予骨化三醇0.50μg(骨化三醇0.50μg治疗组),每日一次。两组患者都给予钙尔奇D 2粒(每粒含离子钙600 mg和活性维生素D 3.125μg),阿仑膦酸钠70 mg每周一次,连续治疗一年。测量、评价并统计两组患者治疗前后和两组患者治疗后腰椎正位(L_(2-4))和左右股骨颈骨密度(Bone Mineral Density,BMD)和腰背疼痛程度。结果治疗一年后两组患者腰椎和股骨颈BMD均显著增加(P0.05);治疗后,骨化三醇0.50μg治疗组腰椎和股骨颈BMD显著高于骨化三醇0.25μg治疗组;疼痛程度显著低于骨化三醇0.25μg治疗组(P0.05)。结论绝经后骨质疏松的三联疗法(钙、活性维生素D、双膦酸盐),骨化三醇0.25μg剂量不足,0.5μg能显著提高临床疗效。
[Abstract]:Objective to compare the clinical efficacy of different doses of ossifying triol in the treatment of postmenopausal osteoporosis.Methods 786 postmenopausal osteoporosis patients were randomly divided into two groups, 393 cases in each group.One group was given ossification triol 0.25 渭 g (ossifying triol 0.25 渭 g) once a day, the other group was given ossification triol 0.50 渭 g (ossifying triol 0.50 渭 g treatment group, once a day).The patients in both groups were treated with calcium 600 mg and active vitamin D 3.125 渭 g / L and alendronate 70 mg once a week for one year.To measure, evaluate and count the lumbar vertebrae anterior and posterior lumbar vertebrae before and after treatment, and the bone Mineral density of left and right femoral necks, and the degree of lumbar back pain, measured, evaluated and counted the two groups of patients before and after treatment.Conclusion the triple therapy of postmenopausal osteoporosis (calcium, active vitamin D, bisphosphonate, 0.25 渭 g calcitriol or less than 0.5 渭 g) can significantly improve the clinical efficacy.
【作者单位】：四川大学华西医院检验科;绵阳市第三人民医院老年综合科骨质疏松专科;
【基金】：四川省科技支撑计划(2010FZ0061);四川省科技支撑计划(2013FZ0051) 四川省杰出青年培养计划(2012JQ0050)
【分类号】：R580

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