钙结合蛋白S100A9在类风湿关节炎患者血清中的表达及意义

发布时间：2018-04-09 21:01

本文选题：钙结合蛋白　切入点：SA　出处：《实用医学杂志》2017年16期

【摘要】：目的检测类风湿关节炎(rheumatoid arthritis,RA)患者血清中S100A9水平,探讨其在RA中的作用及与疾病活动度的关系。方法收集59例不同疾病活动度的RA患者及20例健康志愿者血清。采用酶联免疫吸附实验(ELISA)检测RA患者及健康对照者血清中S100A9水平,分析其与临床及实验室指标相关性。结果 RA患者S100A9水平显著高于健康志愿者(P=0.041 9)。按DAS28评分分为轻、中和重度活动组RA,重度活动组RA S100A9水平显著高于中度(P=0.039 2)、轻度活动组RA患者(P=0.001 3)。相关性分析显示RA患者S100A9水平与DAS28、RF水平、关节肿胀及压痛数呈正相关(P0.01)。结论 RA患者血清S100A9水平显著增高,与疾病活动度密切相关。血清S100A9水平可以作为评估RA疾病活动度标记物之一。
[Abstract]:Objective to investigate the role of S100A9 in rheumatoid arthritis (RA) and its relationship with disease activity.Methods Serum samples of 59 RA patients with different disease activity and 20 healthy volunteers were collected.Serum S100A9 levels in RA patients and healthy controls were detected by Elisa, and the correlation with clinical and laboratory indexes was analyzed.Results the level of S100A9 in RA patients was significantly higher than that in healthy volunteers.According to the DAS28 score, the S100A9 level of RA was significantly higher in the severe active group than that in the moderate active group, and the level of S100A9 in the mild active group was significantly higher than that in the mild active group.Correlation analysis showed that the level of S100A9 was positively correlated with the RF level of DAS28 and the number of joint swelling and tenderness in RA patients (P 0.01).Conclusion Serum S100A9 level in RA patients is significantly higher than that in RA patients, which is closely related to disease activity.Serum S100A9 level can be used as a marker for evaluating RA disease activity.
【作者单位】：南京医科大学第一附属医院风湿病科;南京医科大学第一附属医院心脏病科;
【基金】：国家自然科学基金(编号:81471610,81172845,81471611) 江苏省临床医学科技专项(编号:BL2013034)
【分类号】：R593.22

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