血清TGF-β水平在类风湿性关节炎并发卵巢早衰中的临床分析

发布时间：2018-04-28 16:35

本文选题：类风湿性关节炎 + 卵巢早衰　；参考：《中国地方病防治杂志》2017年05期

【摘要】：目的了解女性类风湿关节炎患者POF的发生率,探讨TGF-β在类风湿关节炎(RA)并发卵巢早衰(POF)的作用及其相关实验室指标的临床分析。方法选择2015年1月-2016年12月确诊的女性类风湿关节炎(符合2009年ACR诊断标准)230例,进一步将其分为RA组与类风湿关节炎并发卵巢早衰组(RA-POF组);收集同期妇产科门诊健康育龄体检者50例为对照组,年龄匹配。分别检测RA组、RA-POF组及对照组女性性激素(FSH、LH、E2)水平及TGF-β水平。结果女性RA患者230例中出现卵巢早衰者29例(12.6%)。与正常对照组及RA组比较,RA-POF组FSH明显升高,E2明显下降,差异具有统计学意义,P0.05。与正常对照组比较,RA-POF组血清TGF-β水平降低,P0.05。结论女性RA患者发生卵巢早衰临床中并不少见,检测血清FSH、LH、E2、TGF-β可以反应卵巢功能情况,临床中应重视并及早发现,及时进行药物干预,减少RA并发POF。
[Abstract]:Objective to understand the incidence of POF in women with rheumatoid arthritis (RA) and to explore the role of TGF- beta in rheumatoid arthritis (RA) complicated with premature ovarian failure (POF) and the clinical analysis of its related laboratory indicators. Methods 230 cases of female rheumatoid arthritis (consistent with 2009 ACR diagnostic criteria) were selected in December -2016, and were further divided into RA Group and rheumatoid arthritis complicated with premature ovarian failure (group RA-POF); 50 cases of healthy childbearing age in the outpatient department of Obstetrics and gynecology were collected at the same time as control group. Age matched. The level of female sex hormone (FSH, LH, E2) and TGF- beta in group RA, RA-POF and control group were detected respectively. Results 29 cases (12.6%) of female RA patients appeared premature ovarian failure (12.6%). Compared with group RA and group RA-POF, the FSH of group RA-POF was obviously increased, and the difference was statistically significant. Compared with the normal control group, the serum TGF- beta level was lower in the RA-POF group. P0.05. concluded that the ovarian premature failure in the female RA patients was not uncommon. The detection of serum FSH, LH, E2, and beta could reflect the ovarian function, and should be paid attention to in clinical practice. And early detection, timely drug intervention, reduce RA and POF.

【作者单位】：西安市第五医院;西安交通大学地方病研究所;
【基金】：陕西省科技发展公关项目(2015SF134) 陕西省自然科学基金项目(2016JM8147) 西安市卫生科研项目(J201603041)
【分类号】：R593.22;R711.75

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