糖尿病急性并发症继发轻度认知功能障碍的预测模型及时间窗分析

发布时间：2018-04-30 20:56

  本文选题：糖尿病 + 糖尿病急性并发症　； 参考：《中风与神经疾病杂志》2017年09期

【摘要】：目的搜集糖尿病急性并发症(Acute diabetic complications,ADC)患者的相关临床指标,构建预测模型以评判继发轻度认知功能障碍(Mild Cognitive Impairment,MCI)的预测价值,并验证其应用性。方法 2014年4月~2016年4月期间湖北省中医院、2015年1月~2016年4月期间湖北省中山医院及武汉市中医院收治的ADC患者为研究队列,搜集相关临床资料,对其进行为期1 y的随访以确认预后转归。依据随访结果预判继发MCI风险的影响性指标,并分析继发MCI时间窗以验证应用性。结果 (1)Cox回归分析显示,ADC患者继发MCI的风险模型由DM病程及HOMA-IR、NSE、IGF-1含量组成,其中IGF-1为保护性因素、其余为风险性因素;(2)DM病程≥13.349 y、HOMA-IR≥4.107 mmol/L*m IU/L、IGF-1107.420 ng/L的ADC患者,继发MCI的时间窗更短,其中DM病程及IGF-1含量的临界值指标具有更高的评判效能。结论 DM病程及HOMA-IR、NSE、IGF-1含量是ADC患者继发MCI的独立影响因素,且DM病程≥13.349 y、IGF-1107.420 ng/L为衡量ADC患者随访期内继发MCI的临界点。
[Abstract]:Objective to collect the clinical indexes of patients with acute diabetic complications of diabetes mellitus, and to establish a predictive model to evaluate the predictive value of mild-cognitive dysfunction (MHD) and verify its application. Methods from April 2014 to April 2016, ADC patients admitted from Hubei Zhongshan Hospital and Wuhan traditional Chinese Medicine Hospital from January 2015 to April 2016 were selected as the study cohort to collect the relevant clinical data. It was followed up for 1 y to confirm prognosis. According to the results of follow-up, the risk of secondary MCI was pre-determined and the secondary MCI time window was analyzed to verify its applicability. Results the risk model of secondary MCI was composed of DM course and HOMA-IRN NSEIGF-1 content, in which IGF-1 was a protective factor, and the rest was a risk factor for ADC whose course of disease 鈮，

本文编号：1826176