中药联合HAART治疗对艾滋病免疫功能重建不全患者TLR相关基因mRNA水平的影响

发布时间：2018-04-30 23:04

  本文选题：中医药 + 艾滋病　； 参考：《中华中医药杂志》2017年12期

【摘要】：目的:观察免疫2号颗粒联合高效抗逆转录病毒治疗(HAART)对46例艾滋病免疫功能重建不全患者人外周血中TLR相关基因m RNA水平的影响,初步探索该疗法对机体免疫调节的作用机制。方法:随机双盲安慰剂对照研究,治疗组23例采用HAART+免疫2号颗粒,对照组23例采用HAART+免疫2号颗粒模拟剂,观察时间1年。观察指标包括CD_4~+T淋巴细胞计数、TLR1、TLR9。结果:治疗后,两组CD_4~+T淋巴细胞计数均上升,治疗组优于对照组,但组间比较差异无统计学意义;治疗组TLR1上升,ΔCT增加2.13±2.96,对照组ΔCT基本持平,两组疗后与疗前差值比较有统计学意义(P=0.046);治疗组TLR9上升,ΔCT增加1.66±2.96,对照组ΔCT值略有下降,两组疗后与疗前差值比较有统计学意义(P=0.04)。结论:中药免疫2号颗粒联合HAART治疗可上调艾滋病免疫功能重建不全患者TLR1、TLR9表达,初步体现中医药干预对提升CD_4~+T淋巴细胞以外免疫调节的作用机制。
[Abstract]:Objective: to observe the effect of immuno 2 granule combined with highly active antiretroviral therapy (HAART) on the level of TLR related gene m RNA in peripheral blood of 46 AIDS patients with incomplete immune function reconstruction. To explore the mechanism of this therapy on immune regulation. Methods: a randomized double-blind placebo control study was conducted in which 23 patients in the treatment group were treated with HAART immunized granule 2 and 23 patients in the control group were treated with HAART immunized granule 2 for one year. The observed indexes included CD4 ~ T lymphocyte count TLR1 and TLR9. Results: after treatment, the number of CD4T lymphocytes increased in both groups, the treatment group was superior to the control group, but there was no significant difference between the two groups, the TLR1 increased 2.13 卤2.96 in the treatment group, and the 螖 CT in the control group was basically unchanged. The difference between the two groups after treatment and before treatment was statistically significant, the TLR9 of the treatment group increased, 螖 CT increased by 1.66 卤2.96, the value of 螖 CT in the control group decreased slightly, and the difference between the two groups after treatment and before treatment was statistically significant. Conclusion: traditional Chinese medicine immunotherapy combined with HAART can upregulate the expression of TLR1 and TLR9 in patients with AIDS-induced immune dysfunction, which indicates the mechanism of Chinese medicine intervention in enhancing the immune regulation of CD4T lymphocytes outside of CD4T lymphocytes.
【作者单位】： 中国中医科学院;广州市第八人民医院;
【基金】：国家自然科学基金项目(No.81503571) 中国中医科学院自主选题项目(No.YZ-1662)~~
【分类号】：R512.91
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本文编号：1826614