颈动脉和下肢动脉粥样硬化分级与2型糖尿病患者心脑血管疾病风险的关系

发布时间：2018-07-01 18:30

本文选题：动脉粥样硬化 + 型糖尿病　；参考：《山东医药》2017年33期

【摘要】：目的探讨颈动脉和下肢动脉粥样硬化分级与2型糖尿病(T2DM)患者心脑血管疾病风险的关系。方法回顾性分析1 262例T2DM患者的临床资料,采集心脑血管疾病病史,采用血管多普勒超声检查颈动脉及下肢动脉,通过动脉硬化分级进行评估,采用Logistic回归方程对颈动脉和下肢动脉粥样硬化分级与心脑血管疾病的相关性进行分析。结果共1 139例患者临床资料纳入结果分析。颈动脉粥样硬化1级283例(24.8%),2级198例(17.4%),3级546例(47.9%),4级112例(9.8%);下肢动脉粥样硬化1级203例(17.8%),2级218例(19.1%),3级654例(57.4%),4级64例(5.6%)。颈动脉与下肢动脉粥样硬化分级具有一致性。有心血管事件者113例(9.9%),无心血管事件者1 026例(90.1%),有脑血管事件者205例(18.0%),无脑血管事件者934例(82%),同时有心血管事件及脑血管事件者76例(6.7%)。多因素Logistic回归分析结果显示与无颈动脉粥样硬化和下肢动脉粥样硬化患者比较,颈动脉粥样硬化和下肢动脉粥样硬化3级和4级患者,心血管和脑血管疾病的患病风险均增加(P均0.05)。心血管疾病患病风险与颈动脉、下肢动脉粥样硬化分级的一致性相关(OR=2.84,P0.05)。结论动脉硬化分级能够评估T2DM患者的颈动脉及下肢动脉的硬化程度,随着外周动脉粥样硬化程度的增加,心脑血管疾病患病风险逐渐增高,颈动脉或下肢动脉粥样硬化斑块形成或存在狭窄均是心脑血管疾病患病的危险因素。
[Abstract]:Objective to investigate the relationship between carotid and lower extremity atherosclerotic grades and the risk of cardiovascular and cerebrovascular diseases in type 2 diabetes mellitus (T2DM). Methods the clinical data of 1 262 patients with T2DM were retrospectively analyzed. The history of cardiovascular and cerebrovascular diseases was collected. Carotid and lower extremity arteries were examined by vascular Doppler ultrasound and evaluated by arteriosclerosis grade. Logistic regression equation was used to analyze the correlation between carotid artery and lower extremity atherosclerosis grade and cardiovascular and cerebrovascular diseases. Results Clinical data of 1 139 patients were analyzed. There were 283 cases (24.8%) of carotid atherosclerosis, 198 cases (17.4%) of grade 2, 546 cases of grade 3 (47.9%), 112 cases of grade 4 (9.8%), 203 cases of grade 1 (17.8%) of lower extremity atherosclerosis, 218 cases of grade 2 (19.1%), 654 cases of grade 3 (57.4%) and 64 cases of grade 4 (5.6%). The classification of carotid artery and lower extremity atherosclerosis is consistent. 113 cases (9.9%) had cardiovascular events, 1026 cases (90.1%) had no cardiovascular events, 205 cases (18.0%) had cerebrovascular events, 934 cases (82%) had no cerebrovascular events, 76 cases (6.7%) had cardiovascular events and cerebrovascular events. Multivariate logistic regression analysis showed that carotid atherosclerosis and lower extremity atherosclerosis were grade 3 and 4 compared with those without carotid atherosclerosis and lower extremity atherosclerosis. The risk of cardiovascular and cerebrovascular diseases increased (P 0.05). The risk of cardiovascular disease was correlated with carotid artery and lower extremity atherosclerosis grade (OR2.84 P 0.05). Conclusion Atherosclerosis grading can evaluate the degree of carotid and lower extremity sclerosis in T2DM patients. With the increase of peripheral atherosclerosis, the risk of cardiovascular and cerebrovascular diseases increases gradually. Carotid or lower extremity atherosclerotic plaque formation or stenosis are risk factors for cardiovascular and cerebrovascular diseases.
【作者单位】：山东省交通医院;山东中医药大学附属医院;
【分类号】：R587.2

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