采用频域OCT观察糖尿病患者早期黄斑区视网膜结构的变化

发布时间：2018-08-08 18:18

【摘要】：目的探讨糖尿病患者黄斑区视网膜结构变化的频域OCT(Cirrus HD-OCT)特征,将其测量参数与正常人群的测量结果进行比较。方法回顾性分析了由Cirrus HDOCT测量的糖尿病患者黄斑区视网膜的结构参数。将糖尿病患眼分为了存在糖尿病视网膜病变(diabetic retinopathy,DR)组和不存在DR组(NDR组),纳入与糖尿病患者年龄和性别分布相匹配的健康对照者(对照组),并对三组的黄斑区神经纤维层和神经节细胞-内丛状层(ganglion cell-inner plexiform layer,GCIPL)厚度等参数进行比较。结果本研究纳入了42例(42眼)2型糖尿病患者(DR组26眼,NDR组16眼),以及30例健康对照者(30眼;对照组)。DR组的GCIPL为(77.2±8.7)μm,NDR组为(79.4±11.3)μm,均小于对照组的(83.2±7.6)μm(均为P0.05)。DR组的最小GCIPL为(65.4±9.3)μm,NDR组为(69.7±7.6)μm,均小于对照组的(76.2±9.2)μm(均为P0.05)。黄斑区各个扇形区域GCIPL厚度中,DR组的上方、鼻侧和下方区域,以及NDR组的鼻下和下方区域明显变薄,与对照组相比差异均有统计学意义(均为P0.05)。DR组和NDR组之间的GCIPL厚度相近,差异均无统计学意义(均为P0.05)。DR组、NDR组和对照组的黄斑区神经纤维层厚度相近,差异均无统计学意义(均为P0.05)。结论糖尿病患者在DR出现之前就已经出现了GCIPL的变薄,频域OCT可被用于监测糖尿病患者早期出现的视网膜神经退行性改变。
[Abstract]:Objective to investigate the frequency-domain OCT (Cirrus HD-OCT (OCT (Cirrus HD-OCT) characteristics of retinal structural changes in diabetic macular area and compare the measured parameters with those of normal subjects. Methods the structural parameters of macular retina measured by Cirrus HDOCT in diabetic patients were analyzed retrospectively. Diabetic eyes were divided into diabetic retinopathy Dr group and non Dr group (NDR group), which included healthy controls matched with age and sex distribution of diabetic patients (control group), and macular nerve in three groups. The thickness of the fibrous layer was compared with the thickness of the ganglion cell-inner plexiform layer (GCIPL). Results 42 patients (42 eyes) with type 2 diabetes mellitus (Dr group, 26 eyes, 16 eyes of NDR group) and 30 healthy controls (30 eyes) were included in this study. The GCIPL of Dr group was (77.2 卤8.7) 渭 m (79.4 卤11.3) 渭 m, which was lower than that of control group (83.2 卤7.6) 渭 m (P0.05). The minimum GCIPL of Dr group was (65.4 卤9.3) 渭 m (69.7 卤7.6) 渭 m, which was lower than that of control group (76.2 卤9.2) 渭 m (P0.05). The thickness of GCIPL in each sector of macular area in Dr group was significantly thinner than that in control group (P0.05). The thickness of GCIPL between Dr group and NDR group was similar to that of Dr group, and the subnasal and inferior regions of NDR group were significantly thinner than that of control group. There was no significant difference (P0.05). The thickness of macular nerve fiber layer in Dr group was similar to that in control group (P0.05). Conclusion GCIPL thinned before Dr appeared in diabetic patients. Frequency domain OCT can be used to monitor retinal neurodegenerative changes in early diabetic patients.
【作者单位】：中山大学中山眼科中心海南眼科医院海南省眼科重点实验室;
【基金】：海南省卫生和计划生育委员会普通医学科研项目(编号:琼卫2014资助-055号)~~
【分类号】：R587.2;R774.1

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