舍格伦综合征患者唾液MMP-9表达与组织病理分级相关性研究

发布时间：2018-09-17 07:03

【摘要】：目的:观察基质金属蛋白酶9(MMP-9)在舍格伦综合征病人唾液中的表达情况,分析其与组织病理分级的相关性,探讨唾液中MMP-9水平作为舍格伦综合征特异性标志物的可能性。方法:采集27例舍格伦综合征患者(实验组)和29例下唇黏液囊肿患者(对照组)的唾液,应用酶联免疫吸附试验(ELISA)检测其MMP-9的表达水平,其中实验组按照病理分级严重程度分为病理分级低的1、2级以及病理分级高的3、4级患者。结果:实验组患者唾液中MMP-9表达水平高于对照组,两组之间表达水平结果比较差异有统计学意义;病理分级高的舍格伦综合征患者组唾液中MMP-9水平高于病理分级低的患者组,两组比较差异有统计学意义。结论:唾液中MMP-9表达水平可能成为舍格伦综合征的一项检测指标,并为临床诊治提供参考依据。
[Abstract]:Objective: to observe the expression of matrix metalloproteinase-9 (MMP-9) in saliva of patients with Seggren's syndrome, and to analyze its correlation with histopathological grading, and to explore the possibility of MMP-9 level in saliva as a specific marker of Schegren's syndrome. Methods: saliva was collected from 27 patients with Sergren's syndrome (experimental group) and 29 patients with mucocele of lower lip (control group). The expression of MMP-9 was detected by enzyme linked immunosorbent assay (ELISA). According to the severity of pathological grade, the experimental group was divided into 1 and 2 grade with low pathological grade and 3 ~ 4 grade with high pathological grade. Results: the expression of MMP-9 in saliva of the experimental group was higher than that of the control group, and the difference between the two groups was statistically significant, and the MMP-9 level in the saliva of the patients with high pathological grade was higher than that of the patients with low pathological grade. The difference between the two groups was statistically significant. Conclusion: the expression level of MMP-9 in saliva may be a marker of Seglgren's syndrome and provide reference for clinical diagnosis and treatment.
【作者单位】：哈尔滨医科大学附属第二医院牙周黏膜科;白城医学高等专科学校口腔学院;哈尔滨医科大学生物信息与科学技术学院;
【基金】：哈尔滨市应用技术研究与开发项目(编号:2014RFXGJ100)
【分类号】：R593.2;R781.5

【参考文献】