睡眠时间与2型糖尿病发病风险关系前瞻性研究的Meta分析
发布时间：2018-09-18 17:31
【摘要】：目的探究睡眠时间与2型糖尿病发病风险的关系,分析睡眠时间与2型糖尿病发病风险的剂量反应关系。方法计算机检索Pub Med、Web of Science、中国知网、万方数据知识服务平台建库至2015-09-22有关睡眠时间与2型糖尿病发病风险的前瞻性研究,通过文献质量评价后,提取调整混杂因素后的相关数据,采用Stata 12.0和R 3.2.2软件分别对数据进行常规Meta分析和剂量反应Meta分析。结果共纳入15个研究,睡眠时间与2型糖尿病发病风险关系的常规Meta分析结果显示,与正常组比较,睡眠时间过短组2型糖尿病发病风险增加36%〔RR=1.36,95%CI(1.23,1.50),P0.001〕,睡眠时间过长组2型糖尿病发病风险增加23%〔RR=1.23,95%CI(1.09,1.39),P=0.001〕。亚组分析结果显示,睡眠时间过短组在除欧洲地区亚组的其他亚组中均增加了2型糖尿病的发病风险(PZ0.05);睡眠时间过长组在两种研究类型亚组、北美地区亚组及随访时间5~10年亚组中均增加了2型糖尿病的发病风险(PZ0.05)。剂量反应Meta分析结果显示,睡眠时间与2型糖尿病发病风险呈非线性剂量反应关系,呈U型关系。与参照睡眠时间7.0 h/晚比较,睡眠时间5.5、6.0、6.5 h/晚2型糖尿病的发病风险为1.20〔95%CI(1.15,1.25)〕、1.10〔95%CI(1.08,1.13)〕、1.04〔95%CI(1.03,1.05)〕,睡眠时间7.5、8.0 h/晚2型糖尿病的发病风险为1.00〔95%CI(0.98,1.01)〕、1.02〔95%CI(0.99,1.06)〕,睡眠时间8.5、9.0、9.5 h/晚2型糖尿病的发病风险为1.07〔95%CI(1.01,1.14)〕、1.14〔95%CI(1.04,1.26)〕、1.23〔95%CI(1.07,1.40)〕。结论睡眠时间过短和过长与2型糖尿病发病风险增加密切相关;睡眠时间7.0 h/晚是2型糖尿病发病风险的危险因素,睡眠时间7.0~8.4 h/晚对2型糖尿病发病风险的影响不明显,而睡眠时间≥8.5 h/晚将导致2型糖尿病发病风险增加。因此,合理的睡眠时间有利于预防2型糖尿病。
[Abstract]:Objective to explore the relationship between sleep time and risk of type 2 diabetes mellitus and analyze the dose response relationship between sleep time and risk of type 2 diabetes mellitus. Methods A prospective study of sleep time and risk of type 2 diabetes mellitus was searched by Pub Med,Web of Science, China knowledge Network, Wanfang data Service platform and 2015-09-22. The quality of the literature was evaluated. The relative data after adjusting confounding factors were extracted and the data were analyzed by Stata 12.0 and R3.2.2 respectively by conventional Meta analysis and dose-response Meta analysis. Results A total of 15 studies were conducted. Routine Meta analysis of the relationship between sleep time and the risk of type 2 diabetes mellitus showed that the risk of type 2 diabetes increased by 36% (RR=1.36,95%CI (1.231.50) / P0.001) in the short sleep duration group compared with the normal group. The risk of type 2 diabetes increased by 23% (RR=1.23,95%CI _ (1.09) 1.39). The results of subgroup analysis showed that the risk of type 2 diabetes mellitus (PZ0.05) was increased in the short sleep duration group in all the subgroups except the European subgroup, and in the two study subgroups in the long sleep duration group. The risk of type 2 diabetes mellitus (PZ0.05) was increased in the North American subgroup and follow-up subgroup for 5 to 10 years. The results of dose response Meta analysis showed that sleep time had a nonlinear dose response relationship with the risk of type 2 diabetes mellitus and a U type relationship. Compared with reference sleep time of 7.0 h / night, the risk of type 2 diabetes was 1.20 (95%CI (1.151.25) 1.10 (95%CI (1.081.13) 1.04 (95%CI (1.031.05), sleep time 7.58.0 h / night diabetes) 1.00 (95%CI (0.981.01) 1.02 (95%CI (0.991.06),). The risk of type 2 diabetes mellitus was 1.07 (95%CI (1.01-1.14) 1.14 (95%CI (1.041.26) 1.23 (95%CI (1.071.40). Conclusion the short and long sleep time is closely related to the increased risk of type 2 diabetes mellitus, and 7.0 h / night sleep time is the risk factor of type 2 diabetes mellitus, but the effect of sleeping time 7.0g 8.4 h / night on the risk of type 2 diabetes mellitus is not obvious. Sleep time 鈮，
本文编号：2248616
[Abstract]:Objective to explore the relationship between sleep time and risk of type 2 diabetes mellitus and analyze the dose response relationship between sleep time and risk of type 2 diabetes mellitus. Methods A prospective study of sleep time and risk of type 2 diabetes mellitus was searched by Pub Med,Web of Science, China knowledge Network, Wanfang data Service platform and 2015-09-22. The quality of the literature was evaluated. The relative data after adjusting confounding factors were extracted and the data were analyzed by Stata 12.0 and R3.2.2 respectively by conventional Meta analysis and dose-response Meta analysis. Results A total of 15 studies were conducted. Routine Meta analysis of the relationship between sleep time and the risk of type 2 diabetes mellitus showed that the risk of type 2 diabetes increased by 36% (RR=1.36,95%CI (1.231.50) / P0.001) in the short sleep duration group compared with the normal group. The risk of type 2 diabetes increased by 23% (RR=1.23,95%CI _ (1.09) 1.39). The results of subgroup analysis showed that the risk of type 2 diabetes mellitus (PZ0.05) was increased in the short sleep duration group in all the subgroups except the European subgroup, and in the two study subgroups in the long sleep duration group. The risk of type 2 diabetes mellitus (PZ0.05) was increased in the North American subgroup and follow-up subgroup for 5 to 10 years. The results of dose response Meta analysis showed that sleep time had a nonlinear dose response relationship with the risk of type 2 diabetes mellitus and a U type relationship. Compared with reference sleep time of 7.0 h / night, the risk of type 2 diabetes was 1.20 (95%CI (1.151.25) 1.10 (95%CI (1.081.13) 1.04 (95%CI (1.031.05), sleep time 7.58.0 h / night diabetes) 1.00 (95%CI (0.981.01) 1.02 (95%CI (0.991.06),). The risk of type 2 diabetes mellitus was 1.07 (95%CI (1.01-1.14) 1.14 (95%CI (1.041.26) 1.23 (95%CI (1.071.40). Conclusion the short and long sleep time is closely related to the increased risk of type 2 diabetes mellitus, and 7.0 h / night sleep time is the risk factor of type 2 diabetes mellitus, but the effect of sleeping time 7.0g 8.4 h / night on the risk of type 2 diabetes mellitus is not obvious. Sleep time 鈮，
本文编号：2248616
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