结直肠癌合并2型糖尿病患者FIB和D-dimer与临床病理特征相关性分析
发布时间:2018-10-25 19:19
【摘要】:目的肿瘤患者体内凝血系统异常活化,而糖尿病患者体内也存在多种促凝和抗凝成分的改变。本研究探讨结直肠癌(colorectal cancer,CRC)合并2型糖尿病(type 2diabetes mellitus,T2DM)以及单纯CRC患者血浆纤维蛋白原(fibrinogen,FIB)和D-二聚体(D-dimer)的变化,及FIB、D-dimer与CRC合并T2DM患者临床病理特征之间的关系。方法选取2011-03-07-2015-09-25天津市人民医院住院患者1 141例。分为合并组274例和CRC组867例,合并组为CRC合并T2DM患者,CRC组为单纯CRC患者。检测空腹血糖(Glu)、FIB和D-dimer,比较两组差异。应用单因素方差分析和t检验比较患者不同临床病理特征FIB水平的差异,应用非参数检验比较患者不同临床病理特征D-dimer水平的差异。结果合并组FIB水平为(4.16±1.066)g/L,高于CRC组的(3.96±0.935)g/L,t=-2.727,P=0.007;合并组D-dimer水平为0.38(0.26,0.67)mg/L,CRC组D-dimer水平为0.40(0.26,0.66)mg/L,两者比较差异无统计学意义,Z=0.168,P=0.867。合并组肿瘤长径≥5cm者FIB(4.41±1.03)g/L高于肿瘤长径5cm者(3.87±1.01)g/L,t=-3.946,P0.001;pT_(3-4)期肿瘤患者FIB(4.21±1.04)g/L高于pT_1~T_2期的(3.78±1.01)g/L,t=-2.295,P=0.023;低、中分化患者FIB水平(4.70±1.00、4.20±1.03)g/L高于高分化患者(3.83±1.10)g/L,F=4.262,P=0.015。合并组女性D-dimer水平0.51(0.32,1.08)mg/L高于男性0.34(0.26,0.55)mg/L,Z=3.797,P0.001;结肠癌患者D-dimer水平0.47(0.31,0.78)mg/L高于直肠癌患者0.34(0.26,0.61)mg/L,Z=2.492,P=0.013;pT_3~T_4期患者D-dimer水平0.39(0.26,0.72)mg/L高于pT_1~T_2期者0.32(0.24,0.42)mg/L,Z=2.090,P=0.037。结论 CRC合并T2DM患者血液处于高凝状态。CRC合并T2DM患者术前高FIB和D-dimer水平与较大的肿瘤直径和较差的肿瘤病理分期、分化有关。
[Abstract]:Objective to study the abnormal activation of coagulation system in tumor patients and the changes of anticoagulant and procoagulant components in diabetic patients. This study was to investigate the changes of plasma fibrinogen (fibrinogen,FIB) and D-dimer (D-dimer) and FIB, in patients with colorectal cancer (colorectal cancer,CRC) complicated with type 2 diabetes mellitus (type 2diabetes mellitus,T2DM) and simple CRC. The relationship between D-dimer and the clinicopathological features of CRC patients with T2DM. Methods 1 141 inpatients in Tianjin people's Hospital were selected from 2011-03-07-2015-09-25. The patients were divided into the combined group (274 cases) and the CRC group (867 cases). The combined group was CRC with T2DM and the CRC group was simple CRC. Fasting blood glucose (Glu), FIB) and D-dimer (D-dimer) were measured and compared between the two groups. Univariate ANOVA and t-test were used to compare the differences of FIB levels in different clinicopathological features and non-parametric tests were used to compare the differences of D-dimer levels in different clinicopathological features of the patients. Results the FIB level in the combined group was (4.16 卤1.066) g / L, higher than that in the CRC group (3.96 卤0.935) g / L) -2.727 g / L, respectively. The D-dimer level in the combined group was 0.38 (0.260.67). The D-dimer level in the mg/L,CRC group was 0.40 (0.260.66) mg/L, but there was no significant difference between the two groups. FIB (4.41 卤1.03) g / L in patients with long diameter 鈮,
本文编号:2294593
[Abstract]:Objective to study the abnormal activation of coagulation system in tumor patients and the changes of anticoagulant and procoagulant components in diabetic patients. This study was to investigate the changes of plasma fibrinogen (fibrinogen,FIB) and D-dimer (D-dimer) and FIB, in patients with colorectal cancer (colorectal cancer,CRC) complicated with type 2 diabetes mellitus (type 2diabetes mellitus,T2DM) and simple CRC. The relationship between D-dimer and the clinicopathological features of CRC patients with T2DM. Methods 1 141 inpatients in Tianjin people's Hospital were selected from 2011-03-07-2015-09-25. The patients were divided into the combined group (274 cases) and the CRC group (867 cases). The combined group was CRC with T2DM and the CRC group was simple CRC. Fasting blood glucose (Glu), FIB) and D-dimer (D-dimer) were measured and compared between the two groups. Univariate ANOVA and t-test were used to compare the differences of FIB levels in different clinicopathological features and non-parametric tests were used to compare the differences of D-dimer levels in different clinicopathological features of the patients. Results the FIB level in the combined group was (4.16 卤1.066) g / L, higher than that in the CRC group (3.96 卤0.935) g / L) -2.727 g / L, respectively. The D-dimer level in the combined group was 0.38 (0.260.67). The D-dimer level in the mg/L,CRC group was 0.40 (0.260.66) mg/L, but there was no significant difference between the two groups. FIB (4.41 卤1.03) g / L in patients with long diameter 鈮,
本文编号:2294593
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