2型糖尿病对老年绝经后女性骨质疏松性骨折风险的影响

发布时间：2018-10-25 20:18

【摘要】：目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)对老年绝经后女性骨质疏松性骨折风险的影响,为预防骨质疏松性骨折及制订相关干预措施提供依据。方法 180例绝经后T2DM女性作为糖尿病组,180例健康绝经后女性作为对照组,比较两组的基本资料、T2DM史、骨折史,骨密度(BMD)、骨转化指标,并比较组间资料和指标差异,生存分析T2DM对骨质疏松性骨折风险的影响。结果糖尿病组腰椎BMD、股骨颈BMD、I型前胶原氨基端肽(procollagen 1 N-terminal peptide,P1NP)显著低于对照组(P0.05),β-Ι型胶原羧基端肽(beta C-terminal telopeptide,β-CTX)组间无显著差异(P0.05);糖尿病组有骨折史人数(率)为25(13.9%),高于对照组12(7.8%)(P0.05),骨折部位分布组间无显著差异(P0.05);生存分析显示T2DM无骨折生存率低于对照组(P0.05)。结论 T2DM可降低老年绝经后女性的骨密度,影响骨转化,可能增加骨质疏松性骨折的风险,应采取措施积极加强预防和干预。
[Abstract]:Objective to investigate the effect of type 2 diabetes mellitus (type 2 diabetes mellitus,T2DM) on the risk of osteoporosis fracture in elderly postmenopausal women, and to provide evidence for preventing osteoporosis fracture and making relevant intervention measures. Methods 180 postmenopausal T2DM women were used as diabetic group and 180 healthy postmenopausal women as control group. The basic data, history of T2DM, history of fracture and bone turnover index of bone mineral density (BMD),) were compared between the two groups. Survival analysis: the effect of T2DM on the risk of osteoporotic fracture. Results the BMD,I type BMD,I procollagen aminoterminal peptide (procollagen 1 N-terminal peptide,P1NP) of lumbar vertebrae in diabetic group was significantly lower than that of control group (P0.05), and 尾-I collagen carboxyl terminal peptide (beta C-terminal telopeptide,) was significantly lower than that of control group (P0.05). There was no significant difference between 尾-CTX groups (P0.05). The number of patients with history of fracture in diabetes group was 25 (13.9%), which was higher than that in control group (12 (7.8%) (P0.05), and there was no significant difference in the distribution of fracture site between the two groups (P0.05). Survival analysis showed that T2DM fracture free survival rate was lower than that of control group (P0.05). Conclusion T2DM can decrease bone mineral density, influence bone turnover and increase the risk of osteoporosis fracture in elderly postmenopausal women. Measures should be taken to strengthen prevention and intervention.
【作者单位】：浙江武警总队杭州医院骨三科;
【分类号】：R580;R587.1;R683

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